Engineered Molecular Therapeutics Targeting Fibrin and the Coagulation System: a Biophysical Perspective
Sign Up to like & getrecommendations! Published in 2022 at "Biophysical Reviews"
DOI: 10.1007/s12551-022-00950-w
Abstract: The coagulation cascade represents a sophisticated and highly choreographed series of molecular events taking place in the blood with important clinical implications. One key player in coagulation is fibrinogen, a highly abundant soluble blood protein… read more here.
Keywords: system biophysical; targeting fibrin; biophysical perspective; coagulation ... See more keywords
Haematopoietic Stem Cell Transplantation in Children Shifts the Coagulation System towards a Pro-Coagulant State.
Sign Up to like & getrecommendations! Published in 2018 at "Thrombosis and haemostasis"
DOI: 10.1055/s-0038-1661394
Abstract: Coagulation system is disturbed by several mechanisms after allogeneic haematopoietic stem cell transplantation (HSCT). We evaluated the effect of HSCT on coagulation system by various conventional and investigational methods in 30 children and adolescents who… read more here.
Keywords: coagulation system; coagulation; cell transplantation; stem cell ... See more keywords
Effect of Glucocorticoid Administration in Intravenous Pulses on Selected Parameters of the Coagulation System
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Clinical Practice"
DOI: 10.1155/2022/3144685
Abstract: Background Changes of the coagulation system are promoted by serious infectious or noninfectious diseases, surgical procedures, and exogenous substances, including drugs. This study aimed to assess the effect of methylprednisolone pulses on selected parameters of… read more here.
Keywords: coagulation; administration; pulses selected; activity ... See more keywords
Should We Replace the Terms Intrinsic and Extrinsic Coagulation Pathways With Tissue Factor Pathway?
Sign Up to like & getrecommendations! Published in 2017 at "Clinical and Applied Thrombosis/Hemostasis"
DOI: 10.1177/1076029616673733
Abstract: Present review highlights some new aspects of the role of individual components of blood coagulation process and proposes a modified concept of hemocoagulation cascade. The role of FXII in the initiation of the so-called intrinsic… read more here.
Keywords: coagulation system; coagulation; tissue factor; pathway ... See more keywords
Role of the coagulation system in the pathogenesis of sickle cell disease.
Sign Up to like & getrecommendations! Published in 2019 at "Blood advances"
DOI: 10.1182/bloodadvances.2019000193
Abstract: Sickle cell disease (SCD) is an inherited monogenic red blood cell disorder affecting millions worldwide. SCD causes vascular occlusions, chronic hemolytic anemia, and cumulative organ damage such as nephropathy, pulmonary hypertension, pathologic heart remodeling, and… read more here.
Keywords: coagulation system; coagulation; sickle cell;
Capillary leak syndrome in sepsis: the role of intrinsic coagulation pathway activation
Sign Up to like & getrecommendations! Published in 2025 at "BMC Infectious Diseases"
DOI: 10.1186/s12879-025-12069-w
Abstract: The coagulation system is closely linked to the inflammatory response and kinin system activation in sepsis, but its contribution to sepsis-associated capillary leak syndrome (SACLS) remains elusive. This study explored the underlying role of the… read more here.
Keywords: coagulation system; leak syndrome; capillary leak; coagulation ... See more keywords
Developmental Hemostasis: The Evolution of our Coagulation System.
Sign Up to like & getrecommendations! Published in 2022 at "NeoReviews"
DOI: 10.1542/neo.23-2-e82
Abstract: Developmental hemostasis describes the evolution of the coagulation system from the neonatal period through adulthood. Neonates have lower levels of coagulation factors and elevated screening levels at birth. These levels can be influenced by various… read more here.
Keywords: hemostasis; coagulation system; developmental hemostasis; evolution coagulation ... See more keywords