Dual Functionality of Bile Acid: Physical Stabilization of Drugs in the Amorphous Form and Solubility Enhancement in Solution.
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DOI: 10.1021/acs.molpharmaceut.2c00294
Abstract: Drugs containing an amino aromatic nitrogen moiety were stabilized in the amorphous form by the surfactant cholic acid (CA). Coamorphous systems of lamotrigine (LAM), pyrimethamine (PYR), and trimethoprim (TRI) were each prepared with CA. Drug-CA… read more here.
Keywords: solubility; coamorphous systems; amorphous form; drug ... See more keywords
The Role of Glass Transition Temperatures in Coamorphous Drug-Amino Acid Formulations.
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DOI: 10.1021/acs.molpharmaceut.8b00650
Abstract: The improved physical stability associated with coamorphous drug-amino acid (AA) formulations may indicate a decrease in mobility of the amorphous drug molecules, compared to the neat amorphous form of the drug. Since the characteristic glass… read more here.
Keywords: amino acid; acid formulations; coamorphous systems; drug ... See more keywords