Effects of oral cobalamin supplementation on serum cobalamin concentrations in dogs with exocrine pancreatic insufficiency: A pilot study.
Sign Up to like & getrecommendations! Published in 2021 at "Veterinary journal"
DOI: 10.1016/j.tvjl.2021.105619
Abstract: The objective of this retrospective study was to evaluate serum cobalamin concentrations before and after oral cobalamin supplementation in dogs with low serum cobalamin concentrations and exocrine pancreatic insufficiency (EPI). Eighteen dogs with serum trypsin-like… read more here.
Keywords: cobalamin supplementation; cobalamin; serum cobalamin; cobalamin concentrations ... See more keywords
Exploring Mechanisms of Biotic Chlorinated Alkane Reduction: Evidence of Nucleophilic Substitution (SN2) with Vitamin B12.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental science & technology"
DOI: 10.1021/acs.est.1c06066
Abstract: Chlorinated alkanes are notorious groundwater contaminants. Their natural reductive dechlorination by microorganisms involves reductive dehalogenases (RDases) containing cobamide as a cofactor. However, underlying mechanisms of reductive dehalogenation have remained uncertain. Here, observed products, radical trap… read more here.
Keywords: cobalamin; sn2; nucleophilic substitution; substitution sn2 ... See more keywords
Cryo-EM structure of human lysosomal cobalamin exporter ABCD4
Sign Up to like & getrecommendations! Published in 2019 at "Cell Research"
DOI: 10.1038/s41422-019-0222-z
Abstract: Dear Editor, Cobalamin, also known as vitamin B12, can only be biosynthesized by certain bacteria and archaea. As an essential nutrient for humans, it should be obtained from daily food. Exogenous cobalamin is taken up… read more here.
Keywords: supplementary information; abcd4; structure; fig ... See more keywords
Anaerobic demethylation of guaiacyl-derived monolignols enabled by a designed artificial cobalamin methyltransferase fusion enzyme
Sign Up to like & getrecommendations! Published in 2023 at "RSC Advances"
DOI: 10.1039/d2ra08005b
Abstract: Lignin-derived aryl methyl ethers (e.g. coniferyl alcohol, ferulic acid) are expected to be a future carbon source for chemistry. The well-known P450 dependent biocatalytic O-demethylation of these aryl methyl ethers is prone to side product… read more here.
Keywords: cobalamin; fusion; demethylation; fusion enzyme ... See more keywords
Utilization of Cobalamin Is Ubiquitous in Early-Branching Fungal Phyla
Sign Up to like & getrecommendations! Published in 2021 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evab043
Abstract: Abstract Cobalamin is a cofactor present in essential metabolic pathways in animals and one of the water-soluble vitamins. It is a complex compound synthesized solely by prokaryotes. Cobalamin dependence is scattered across the tree of… read more here.
Keywords: cobalamin ubiquitous; utilization cobalamin; branching fungal; cobalamin ... See more keywords
A functional genetic screen reveals sequence preferences within a key tertiary interaction in cobalamin riboswitches required for ligand selectivity
Sign Up to like & getrecommendations! Published in 2018 at "Nucleic Acids Research"
DOI: 10.1093/nar/gky539
Abstract: Abstract Riboswitches are structured mRNA sequences that regulate gene expression by directly binding intracellular metabolites. Generating the appropriate regulatory response requires the RNA rapidly and stably acquire higher-order structure to form the binding pocket, bind… read more here.
Keywords: functional genetic; cobalamin riboswitches; genetic screen; sequence ... See more keywords
Potential mechanism for hyperhomocysteinemia in Greyhound dogs
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Veterinary Internal Medicine"
DOI: 10.1111/jvim.16700
Abstract: Abstract Background Greyhounds have been reported to have hyperhomocysteinemia (HHC), but the underlying mechanisms and clinical implications are unclear. Hypothesis Our primary aim was to assess serum concentrations of homocysteine (HCy) and related analytes in… read more here.
Keywords: cobalamin; greyhounds median; serum; methionine ... See more keywords
AB0507 Cobalamin (VITAMIN B12) status in patients with antiphospholipid syndrome (APS), its association with atherosclerotic vascular lesions
Sign Up to like & getrecommendations! Published in 2017 at "Annals of the Rheumatic Diseases"
DOI: 10.1136/annrheumdis-2017-eular.3006
Abstract: Background Cobalamin (vitamin B12) insufficienty is associated with the development of many diseases. It is known that the growth of clinical and subclinical manifestations of atherosclerotic vascular lesions are often associated with low cobalamin level.… read more here.
Keywords: status; vitamin b12; cobalamin vitamin; atherosclerotic vascular ... See more keywords
The Relationship of Cobalamin and/or Folate to the Patient-Centred Outcomes in Multiple Sclerosis: A Systematic Review and Meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "Nutrition and Health"
DOI: 10.1177/02601060221080240
Abstract: Background: To examine the relationship of vitamin B12 and folate concentrations to cognitive function, fatigue measures, physical function, quality of life (patient-centred outcomes) and homocysteine plasma concentrations (intermediate marker of cobalamin and folate deficiency) for… read more here.
Keywords: cobalamin; patient centred; centred outcomes; healthy controls ... See more keywords
Newly Diagnosed Pernicious Anemia Can be Treated with a Single Megadose of Cobalamin. Results of a Pilot Trial
Sign Up to like & getrecommendations! Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-118611
Abstract: Introduction: Pernicious anemia is the leading cause of vitamin B12 deficiency worldwide, caused by an autoimmune reaction against parietal cells in the gastric mucosa leading to B12 absorption impairment. The treatment of pernicious anemia is… read more here.
Keywords: range; treatment; pernicious anemia; cobalamin ... See more keywords
High cobalamin levels as a five-year risk predictor for developing haematological cancer.
Sign Up to like & getrecommendations! Published in 2022 at "Minerva medica"
DOI: 10.23736/s0026-4806.22.07336-0
Abstract: OBJECTIVE A high cobalamin level has been related to non-malignant diseases (mainly liver diseases, alcoholism, and renal diseases) and cancer (haematological malignancies and solid cancers such as liver and stomach cancer). However, a previous high… read more here.
Keywords: cobalamin; high cobalamin; cobalamin levels; development ... See more keywords