Enantioselective synthesis of (R)-Cinacalcet via cobalt-catalysed asymmetric Negishi cross-coupling.
Sign Up to like & getrecommendations! Published in 2019 at "Chirality"
DOI: 10.1002/chir.23085
Abstract: A novel enantioselective synthesis of (R)-cinacalcet with 99% enantiomeric excesses (ee) has been achieved. The main strategies of the approach include a gram-scale cobalt-catalysed asymmetric cross-coupling of racemic ester with arylzinc reagent, Hoffman-type rearrangement of… read more here.
Keywords: catalysed asymmetric; cobalt catalysed; synthesis cinacalcet; cross coupling ... See more keywords
Cobalt-catalysed C–H methylation for late-stage drug diversification
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DOI: 10.1038/s41557-020-0475-7
Abstract: The magic methyl effect is well acknowledged in medicinal chemistry, but despite its significance, accessing such analogues via derivatization at a late stage remains a pivotal challenge. In an effort to mitigate this major limitation,… read more here.
Keywords: late stage; methylation; chemistry; cobalt catalysed ... See more keywords
N-Iminopyridinium ylide-directed, cobalt-catalysed coupling of sp2 C-H bonds with alkynes.
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DOI: 10.1039/d0cc05294a
Abstract: N-Iminopyridinium ylides are competent monodentate directing groups for cobalt-catalysed annulation of sp2 C-H bonds with internal alkynes. The pyridine moiety in the ylide serves as an internal oxidant and is cleaved during the reaction. The… read more here.
Keywords: sp2 bonds; iminopyridinium ylide; ylide directed; cobalt catalysed ... See more keywords
Photoexcited cobalt catalysed endo-selective alkyl Heck reaction.
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DOI: 10.1039/d2cc06967a
Abstract: Herein, we report an intramolecular endo-selective Heck reaction of iodomethylsilyl ethers of phenols and alkenols. The reaction leads to the formation of seven- and eight-membered siloxycycles in excellent yields, which could be further converted into… read more here.
Keywords: heck reaction; endo selective; reaction; cobalt catalysed ... See more keywords