Bioinspired Cobalt-Catalysis Enables Generation of Nucleophilic Radicals from Oxetanes
Sign Up to like & getrecommendations! Published in 2022 at "Organic Letters"
DOI: 10.1021/acs.orglett.2c00355
Abstract: Oxetanes are valuable building blocks due to their well-explored propensity to undergo ring-opening reactions with nucleophiles. However, their application as precursors of radical species is still elusive. Herein, we present a bioinspired cobalt-catalysis-based strategy to… read more here.
Keywords: catalysis enables; cobalt catalysis; nucleophilic radicals; bioinspired cobalt ... See more keywords
PCET-Mediated Ring-Opening Alkenylation of Cycloalkanols via Dual Photoredox and Cobalt Catalysis.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c03894
Abstract: The construction of molecular skeletons and modification of molecules using widely available and easily prepared alcohols as radical precursors for coupling reactions are significant and challenging subjects. We herein report a straightforward strategy for the… read more here.
Keywords: opening alkenylation; cobalt catalysis; dual photoredox; alkenylation cycloalkanols ... See more keywords
Merging Halogen-Atom Transfer (XAT) and Cobalt Catalysis to Override E2-Selectivity in the Elimination of Alkyl Halides: A Mild Route toward contra-Thermodynamic Olefins.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.1c06768
Abstract: We report here a mechanistically distinct tactic to carry E2-type eliminations on alkyl halides. This strategy exploits the interplay of α-aminoalkyl radical-mediated halogen-atom transfer (XAT) with desaturative cobalt catalysis. The methodology is high-yielding, tolerates many… read more here.
Keywords: alkyl halides; atom transfer; contra thermodynamic; transfer xat ... See more keywords
C-H bond functionalization by high-valent cobalt catalysis: current progress, challenges and future perspectives.
Sign Up to like & getrecommendations! Published in 2021 at "Chemical communications"
DOI: 10.1039/d1cc04382j
Abstract: Over the last decade, high-valent cobalt catalysis has earned a place in the spotlight as a valuable tool for C-H activation and functionalization. Since the discovery of its unique reactivity, more and more attention has… read more here.
Keywords: high valent; cobalt; cobalt catalysis; valent cobalt ... See more keywords