Tenofovir disoproxil fumarate/emtricitabine plus ritonavir-boosted lopinavir or cobicistat-boosted elvitegravir as a single-tablet regimen for HIV post-exposure prophylaxis
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dkx246
Abstract: Objectives To assess HIV-1 post-exposure prophylaxis (PEP) non-completion at day 28, comparing ritonavir-boosted lopinavir versus cobicistat-boosted elvitegravir as a single-tablet regimen (STR), using tenofovir disoproxil fumarate/emtricitabine with both of these therapies. Methods A prospective, open,… read more here.
Keywords: elvitegravir cobicistat; ritonavir; cobicistat; versus ... See more keywords
Pharmacokinetics of dolutegravir with and without darunavir/cobicistat in healthy volunteers
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Antimicrobial Chemotherapy"
DOI: 10.1093/jac/dky384
Abstract: Background Dolutegravir combined with darunavir/cobicistat is a promising NRTI-sparing and/or salvage strategy for the treatment of HIV-1 infection. Methods This Phase I, open-label, 57 day, crossover, pharmacokinetic (PK) study, enrolled healthy volunteers aged 18-65 years, who were… read more here.
Keywords: darunavir cobicistat; healthy volunteers; cobicistat; drv cobi ... See more keywords
Pharmacokinetics of atazanavir boosted with cobicistat in pregnant and postpartum women with HIV.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of acquired immune deficiency syndromes"
DOI: 10.1097/qai.0000000000002856
Abstract: BACKGROUND This study evaluated atazanavir and cobicistat pharmacokinetics during pregnancy compared to postpartum and in infant washout samples. SETTING A nonrandomized, open-label, parallel-group, multi-center prospective study of atazanavir and cobicistat pharmacokinetics in pregnant women with… read more here.
Keywords: atazanavir cobicistat; women hiv; second trimester; cobicistat ... See more keywords
Pharmacokinetics of Temsavir, the Active Moiety of the HIV-1 Attachment Inhibitor Prodrug, Fostemsavir, Coadministered with Cobicistat, Etravirine, Darunavir/Cobicistat, or Darunavir/Ritonavir with or without Etravirine in Healthy Participants
Sign Up to like & getrecommendations! Published in 2022 at "Antimicrobial Agents and Chemotherapy"
DOI: 10.1128/aac.02251-21
Abstract: Fostemsavir is a prodrug of temsavir, a first-in-class attachment inhibitor that binds directly to HIV-1 gp120, preventing initial viral attachment and entry into host CD4+ T cells with demonstrated efficacy in phase 2 and 3.… read more here.
Keywords: attachment; fostemsavir; drv; cobicistat ... See more keywords
The FDA-Approved Drug Cobicistat Synergizes with Remdesivir To Inhibit SARS-CoV-2 Replication In Vitro and Decreases Viral Titers and Disease Progression in Syrian Hamsters
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DOI: 10.1128/mbio.03705-21
Abstract: The lack of effective antiviral treatments against SARS-CoV-2 is a significant limitation in the fight against the COVID-19 pandemic. Single-drug regimens have so far yielded limited results, indicating that combinations of antivirals might be required,… read more here.
Keywords: fda approved; sars cov; drug; cobicistat ... See more keywords
Combination Therapy with Tenofovir Disoproxil Fumarate/Emtricitabine/Elvitegravir/Cobicistat Plus Darunavir Once Daily in Antiretroviral-Naive and Treatment-Experienced Patients: A Retrospective Review
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the International Association of Providers of AIDS Care"
DOI: 10.1177/2325957417752260
Abstract: Background: Patients with drug-resistant HIV often require complex antiretroviral regimens. However, combining fixed-dose combination tablets such as tenofovir–disoproxil–fumarate, emtricitabine, and cobicistat-boosted elvitegravir (TDF/FTC/EVG/cobi) with darunavir (DRV) can provide a simple, once-daily (QD), 2-tablet regimen for… read more here.
Keywords: combination; fumarate emtricitabine; disoproxil fumarate; tenofovir disoproxil ... See more keywords
Use of Darunavir-Cobicistat as a Treatment Option for Critically Ill Patients with SARS-CoV-2 Infection
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DOI: 10.3349/ymj.2020.61.9.826
Abstract: We retrospectively reviewed patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections who were admitted to an intensive care unit in Daegu, South Korea. The outcomes of patients who did (cases) or did not… read more here.
Keywords: darunavir cobicistat; cobicistat; critically ill; cobicistat group ... See more keywords
Assessing Bias Introduced in Estimated Glomerular Filtration Rate by the Inhibition of Creatinine Tubular Secretion from Common Antiretrovirals
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DOI: 10.3851/imp3373
Abstract: Background Researchers must often rely on creatinine measurements to assess kidney function because direct glomerular filtration rates (GFR) and cystatin-c are rarely measured in routine clinical settings. However, HIV treatments often include dolutegravir, raltegravir, rilpivirine… read more here.
Keywords: egfr min; egfr correction; cobicistat; secretion ... See more keywords