Lipidomic changes in the rat hippocampus following cocaine conditioning, extinction, and reinstatement of drug‐seeking
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1451
Abstract: Cocaine dependence affects millions of individuals worldwide; however, there are no pharmacotherapeutic and/or diagnostic solutions. Recent evidence suggests a role for lipid signaling in the development and maintenance of addiction, highlighting the need to understand… read more here.
Keywords: changes rat; hippocampus following; lipidomic changes; following cocaine ... See more keywords
Profiling cocaine residues and pyrolytic products in wastewater by mixed-mode liquid chromatography-tandem mass spectrometry.
Sign Up to like & getrecommendations! Published in 2019 at "Drug testing and analysis"
DOI: 10.1002/dta.2590
Abstract: This work provides a new analytical method for the determination of cocaine, its metabolites benzoylecgonine and cocaethylene, the pyrolytic products anhydroecgonine and anhydroecgonine methyl ester, and the pharmaceutical levamisole in wastewater. Samples were solid-phase extracted… read more here.
Keywords: chromatography tandem; pyrolytic products; mass; liquid chromatography ... See more keywords
Performance evaluation of handheld Raman spectroscopy for cocaine detection in forensic case samples
Sign Up to like & getrecommendations! Published in 2020 at "Drug Testing and Analysis"
DOI: 10.1002/dta.2993
Abstract: Abstract Handheld Raman spectroscopy is an emerging technique for rapid on‐site detection of drugs of abuse. Most devices are developed for on‐scene operation with a user interface that only shows whether cocaine has been detected.… read more here.
Keywords: detection; case samples; performance; spectroscopy ... See more keywords
Chiral pharmacokinetics of tetramisole stereoisomers - enantioselective quantification of levamisole and dexamisole in serum samples from users of adulterated cocaine.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3227
Abstract: Phenyltetrahydroimidazothiazole (PTHIT, tetramisole) ist the most frequently used adulterant of cocaine and exists in the two enantiomeric forms levamsiole (S) and dexamisole (R). Existing studies show diverse fractions of samples containing enantiopure levamsiole, levamisole-enriched mixtures… read more here.
Keywords: chiral pharmacokinetics; pthit; serum samples; positive samples ... See more keywords
DRUG-IMPAIRED DRIVING AND TRAFFIC COLLISIONS: STUDY ON A CROSS SECTION OF THE ITALIAN POPULATION.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3366
Abstract: The present study focuses on the association between road accidents and the presence of drugs of abuse markers in the biological fluids of the drivers. Biological fluids collected from 1,236 drivers involved in road accidents… read more here.
Keywords: non fatal; road; fatal crashes; cocaine ... See more keywords
An aptamer‐based paper microfluidic device for the colorimetric determination of cocaine
Sign Up to like & getrecommendations! Published in 2018 at "ELECTROPHORESIS"
DOI: 10.1002/elps.201700254
Abstract: A method utilizing paper microfluidics coupled with gold nanoparticles and two anticocaine aptamers has been developed to detect seized cocaine samples. The ready‐to‐use format involves the use of a paper strip that produces a color… read more here.
Keywords: based paper; paper microfluidic; aptamer based; paper ... See more keywords
[18F]FDG brain uptake of C57Bl/6 male mice is affected by locomotor activity after cocaine use: A small animal positron emission tomography study
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Neuroscience Research"
DOI: 10.1002/jnr.25102
Abstract: We verified if cocaine‐induced peripheral activation might disrupt [18F]FDG brain uptake after a cocaine challenge and suggested an optimal protocol to measure cocaine‐induced brain metabolic alterations in mice. C57Bl/6 male mice were injected with [18F]FDG… read more here.
Keywords: 18f fdg; fdg brain; use; cocaine ... See more keywords
Imaging phosphodiesterase‐10a availability in cocaine use disorder with [11C]IMA107 and PET
Sign Up to like & getrecommendations! Published in 2019 at "Synapse"
DOI: 10.1002/syn.22070
Abstract: Phosphodiesterase‐10a (PDE10a) is located exclusively in medium spiny neurons (MSN). Rodent studies show an increase in striatal MSN spine density following exposure to cocaine. These increases in MSN spine density are suggested to underlie neurobiological… read more here.
Keywords: 11c ima107; cocaine use; phosphodiesterase 10a; cocaine ... See more keywords
Determination of Cocaine and Metabolites in Dried Blood Spots by LC-MS/MS.
Sign Up to like & getrecommendations! Published in 2019 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-8823-5_23
Abstract: Cocaine is one of the most common illegal drugs in Europe and other parts of the world. It is mainly metabolized to benzoylecgonine and ecgonine methyl ester but also to minor metabolites such as norcocaine… read more here.
Keywords: blood spots; determination cocaine; dried blood; cocaine metabolites ... See more keywords
Ethanol addictively enhances the in vitro cardiotoxicity of cocaine through oxidative damage, energetic deregulation, and apoptosis
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Toxicology"
DOI: 10.1007/s00204-018-2227-7
Abstract: Cocaine (COC) is frequently consumed in polydrug abuse settings, and ethanol (EtOH) is the most prominent co-abused substance. Clinical data and experimental evidence suggest that the co-administration of COC with EtOH can be more cardiotoxic… read more here.
Keywords: ethanol addictively; apoptosis; vitro cardiotoxicity; cardiotoxicity ... See more keywords
Naloxone effects on extinction of ethanol- and cocaine-induced conditioned place preference in mice
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4672-z
Abstract: RationalePrevious studies found that naloxone (NLX) facilitated choice extinction of ethanol conditioned place preference (CPP) using long (60 min) test sessions, but there is little information on the variables determining this effect.ObjectivesThese studies examined repeated exposure… read more here.
Keywords: extinction ethanol; extinction; effect; cpp ... See more keywords