SA111 FURTHER EVIDENCE FOR THE ASSOCIATION BETWEEN SYT1-RS2251214 AND USE OF STIMULANTS: CRACK COCAINE ADDICTION SUSCEPTIBILITY AND SEVERITY
Sign Up to like & getrecommendations! Published in 2019 at "European Neuropsychopharmacology"
DOI: 10.1016/j.euroneuro.2017.08.183
Abstract: Background Synaptotagmin 1 is expressed in synaptic vesicles and plays an important role on neuroexocytosis. A variant in its encoding gene (SYT1-rs2251214) has been associated with ADHD susceptibility and with other externalizing behaviors and comorbidities.… read more here.
Keywords: susceptibility; cocaine addiction; crack cocaine; cocaine ... See more keywords
Cannabidiol prevents several of the behavioral alterations related to cocaine addiction in mice
Sign Up to like & getrecommendations! Published in 2021 at "Progress in Neuro-Psychopharmacology and Biological Psychiatry"
DOI: 10.1016/j.pnpbp.2021.110390
Abstract: Cocaine dependence is a highly prevalent disease in modern society and lacks an effective treatment. Cannabidiol (CBD), a major non-psychoactive constituent of Cannabis sativa, has been shown to be a promising tool in the management… read more here.
Keywords: cocaine addiction; cocaine induced; cannabidiol; related cocaine ... See more keywords
Stress-induced vulnerability to develop cocaine addiction depends on cofilin modulation
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Stress"
DOI: 10.1016/j.ynstr.2021.100349
Abstract: Actin dynamics in dendritic spines can be associated with the neurobiological mechanisms supporting the comorbidity between stress exposure and cocaine increase rewards. The actin cytoskeleton remodeling in the nucleus accumbens (NA) has been implicated in… read more here.
Keywords: cocaine addiction; stress induced; stress; cofilin ... See more keywords
Machine Learning Analysis of Cocaine Addiction Informed by DAT, SERT, and NET-Based Interactome Networks.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of chemical theory and computation"
DOI: 10.1021/acs.jctc.2c00002
Abstract: Cocaine addiction is a psychosocial disorder induced by the chronic use of cocaine and causes a large number of deaths around the world. Despite decades of effort, no drugs have been approved by the Food… read more here.
Keywords: machine learning; cocaine addiction; dat sert; addiction ... See more keywords
Motivational factors modulate left frontoparietal network during cognitive control in cocaine addiction
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DOI: 10.1111/adb.12820
Abstract: Cocaine addiction is characterized by alterations in motivational and cognitive processes involved in goal‐directed behavior. Recent studies have shown that addictive behaviors can be attributed to alterations in the activity of large functional networks. The… read more here.
Keywords: addiction; left frontoparietal; cocaine addiction; frontoparietal network ... See more keywords
Differential expression of miR‐1249‐3p and miR‐34b‐5p between vulnerable and resilient phenotypes of cocaine addiction
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DOI: 10.1111/adb.13201
Abstract: Cocaine addiction is a complex brain disorder involving long‐term alterations that lead to loss of control over drug seeking. The transition from recreational use to pathological consumption is different in each individual, depending on the… read more here.
Keywords: cocaine addiction; addiction; mir; resilient phenotypes ... See more keywords
Prepulse Inhibition in Cocaine Addiction and Dual Pathologies
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DOI: 10.3390/brainsci11020269
Abstract: Cocaine addiction is frequently associated with different psychiatric disorders, especially schizophrenia and antisocial personality disorder. A small number of studies have used prepulse inhibition (PPI) as a discriminating factor between these disorders. This work evaluated… read more here.
Keywords: personality disorder; disorder; cocaine addiction; prepulse inhibition ... See more keywords