Acute effects of intravenous cocaine administration on serum concentrations of ghrelin, amylin, glucagon-like peptide-1, insulin, leptin and peptide YY and relationships with cardiorespiratory and subjective responses.
Sign Up to like & getrecommendations! Published in 2017 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2017.07.033
Abstract: BACKGROUND Food intake and use of drugs of abuse like cocaine share common central and peripheral physiological pathways. Appetitive hormones play a major role in regulating food intake; however, little is known about the effects… read more here.
Keywords: insulin; subjective responses; cocaine administration; cocaine ... See more keywords
Interaction of JNK and mGluR5 in the regulation of psychomotor behaviours after repeated cocaine administration
Sign Up to like & getrecommendations! Published in 2022 at "Addiction Biology"
DOI: 10.1111/adb.13127
Abstract: Activation of protein kinases after cocaine administration controls psychomotor behaviours by interacting with metabotropic receptors in the brain. This study identified how c‐Jun N‐terminal kinase (JNK) interacts with metabotropic glutamate receptor 5 (mGluR5) in vitro… read more here.
Keywords: interaction; cocaine administration; jnk; jnk mglur5 ... See more keywords
Thymic involution caused by repeated cocaine administration includes apoptotic cell loss followed by ectopic adipogenesis
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DOI: 10.1371/journal.pone.0277032
Abstract: Cocaine abuse has a negative impact on the immune system. To investigate the adverse effects of binge cocaine administration on lymphoid organs such as thymus and spleen, we examined the effects of repeated intravenous (i.v.)… read more here.
Keywords: ectopic adipogenesis; cocaine administration; loss; cocaine ... See more keywords
High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1061578
Abstract: Cocaine’s addictive properties stem from its capacity to increase tonic extracellular dopamine levels in the nucleus accumbens (NAc). The ventral tegmental area (VTA) is a principal source of NAc dopamine. To investigate how high frequency… read more here.
Keywords: cocaine administration; dopamine; dopamine levels; tonic dopamine ... See more keywords
Activation of Protein Kinase G After Repeated Cocaine Administration Is Necessary for the Phosphorylation of α-Amino-3-Hydroxy-5-Methyl-4-Isoxazolepropionic Acid Receptor GluA1 at Serine 831 in the Rat Nucleus Accumbens
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2018.00263
Abstract: Phosphorylation of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors in the striatum plays a crucial role in regulating the receptor-coupled signaling cascades leading to behavioral changes associated with psychostimulant exposure. The present study determined if activation of protein… read more here.
Keywords: glua1; repeated cocaine; receptor; phosphorylation ... See more keywords
Contraction Band Necrosis with Dephosphorylated Connexin 43 in Rat Myocardium after Daily Cocaine Administration
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms231911978
Abstract: Contraction band necrosis (CBN) is a common abnormality found in the myocardium of cocaine abusers, but is rarely reported in experimental models of cocaine abuse. Connexin 43 (Cx43) is essential for cardiac intercellular communication and… read more here.
Keywords: cbn; cocaine administration; cocaine; cardiac cx43 ... See more keywords