Contributions of prolonged contingent and non-contingent cocaine exposure to escalation of cocaine intake and glutamatergic gene expression
Sign Up to like & getrecommendations! Published in 2017 at "Psychopharmacology"
DOI: 10.1007/s00213-017-4798-z
Abstract: Similar to the pattern observed in people with substance abuse disorders, laboratory animals will exhibit escalation of cocaine intake when the drug is available over prolonged periods of time. Here, we investigated the contribution of… read more here.
Keywords: cocaine intake; contingent; expression; cocaine ... See more keywords
The effects of social contact on cocaine intake in female rats.
Sign Up to like & getrecommendations! Published in 2017 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2017.03.027
Abstract: BACKGROUND Studies conducted in male rats report that social contact can either facilitate or inhibit drug intake depending on the behavior of social partners. The purpose of the present study was to: (1) examine the… read more here.
Keywords: partner; contact cocaine; cocaine intake; social contact ... See more keywords
Cocaine-associated decision-making: Toward isolating preference
Sign Up to like & getrecommendations! Published in 2019 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2019.03.025
Abstract: Ever-increasing evidence suggests that substance use disorder is mediated by decision-making processes, and as such, providing nondrug alternatives can shift maladaptive preferences away from drug reinforcers, such as cocaine. Of note, a recent hypothesis suggests… read more here.
Keywords: decision making; preference; choice; cocaine intake ... See more keywords
Preclinical support for the therapeutic potential of zolmitriptan as a treatment for cocaine use disorders
Sign Up to like & getrecommendations! Published in 2020 at "Translational Psychiatry"
DOI: 10.1038/s41398-020-00956-6
Abstract: Serotonin 1B receptor (5-HT 1B R) agonists enhance cocaine intake in rats during daily self-administration but attenuate cocaine intake after prolonged abstinence. Here we investigated whether the less selective but clinically available 5-HT 1D/1B R… read more here.
Keywords: zolmitriptan; treatment cocaine; cocaine use; cocaine intake ... See more keywords
5-HT1B receptor agonist attenuates cocaine self-administration after protracted abstinence and relapse in rats
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Psychopharmacology"
DOI: 10.1177/02698811211019279
Abstract: Background: The 5-HT1B receptor (5-HT1BR) agonist, CP94253, enhances cocaine intake during maintenance of self-administration (SA) but attenuates intake after 21 days of forced abstinence in male rats. Aims: We examined whether CP94253 attenuates cocaine intake in… read more here.
Keywords: self administration; cocaine intake; relapse; abstinence ... See more keywords