Association of dopamine D2-like and D3 receptor function with initial sensitivity to cocaine reinforcement in male rhesus monkeys
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DOI: 10.2139/ssrn.4333048
Abstract: Identifying neurobiological characteristics that predict the development of cocaine use disorder would be of great value in prevention efforts. Because of their importance in mediating the abuse-related effects of cocaine, brain dopamine receptors are logical… read more here.
Keywords: sensitivity cocaine; sensitivity; d2r availability; dopamine ... See more keywords
Epac2 in midbrain dopamine neurons contributes to cocaine reinforcement via enhancement of dopamine release
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DOI: 10.7554/elife.80747
Abstract: Repeated exposure to drugs of abuse results in an upregulation of cAMP signaling in the mesolimbic dopamine system, a molecular adaptation thought to be critically involved in the development of drug dependence. Exchange protein directly… read more here.
Keywords: epac2; dopamine release; dopamine; dopamine neurons ... See more keywords