Sex differences in incentive-sensitization produced by intermittent access cocaine self-administration
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DOI: 10.1007/s00213-018-5091-5
Abstract: RationaleIntermittent Access (IntA) cocaine self-administration, which models intermittent patterns of cocaine use in humans during the transition to addiction, is especially effective in producing incentive-sensitization and other addiction-like behavior in male rats. However, female rats… read more here.
Keywords: self administration; cocaine; incentive sensitization; sensitization ... See more keywords
Effects of a histone deacetylase 3 inhibitor on extinction and reinstatement of cocaine self-administration in rats
Sign Up to like & getrecommendations! Published in 2018 at "Psychopharmacology"
DOI: 10.1007/s00213-018-5122-2
Abstract: RationaleA challenge in treating substance use disorder is that successful treatment often does not persist, resulting in relapse and continued drug seeking. One approach to persistently weaken drug-seeking behaviors is to pair exposure to drug-associated… read more here.
Keywords: inhibitor; reinstatement; extinction; drug ... See more keywords
Effects of chronic cocaine self-administration and N-acetylcysteine on learning, cognitive flexibility, and reinstatement in nonhuman primates
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05211-5
Abstract: RationaleCocaine use disorder (CUD) is associated with cognitive deficits that have been linked to poor treatment outcomes. An improved understanding of cocaine’s deleterious effects on cognition may help optimize pharmacotherapies. Emerging evidence implicates abnormalities in… read more here.
Keywords: cocaine; self administration; cognitive flexibility; cocaine self ... See more keywords
Effects of ethanol on cocaine self-administration in monkeys responding under a second-order schedule of reinforcement.
Sign Up to like & getrecommendations! Published in 2017 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2016.11.002
Abstract: BACKGROUND Concurrent alcohol use among cocaine abusers is common but the behavioral variables that promote co-abuse are not well understood. The present study examined the effects of intragastric (i.g.) ethanol (EtOH) administration in monkeys responding… read more here.
Keywords: self administration; administration; schedule; administration monkeys ... See more keywords
Neurobiological substrates of persistent working memory deficits and cocaine-seeking in the prelimbic cortex of rats with a history of extended access to cocaine self-administration
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DOI: 10.1016/j.nlm.2019.03.007
Abstract: Cocaine use disorder (CUD) is associated with prefrontal cortex dysfunction and cognitive deficits that may contribute to persistent relapse susceptibility. As the relationship between cognitive deficits, cortical abnormalities and drug seeking is poorly understood, development… read more here.
Keywords: self administration; working memory; cocaine; access ... See more keywords
Cocaine self-administration specifically increases A2AR-D2R and D2R-sigma1R heteroreceptor complexes in the rat nucleus accumbens shell. Relevance for cocaine use disorder
Sign Up to like & getrecommendations! Published in 2017 at "Pharmacology Biochemistry and Behavior"
DOI: 10.1016/j.pbb.2017.03.003
Abstract: &NA; Adenosine 2A receptor (A2AR) agonists were indicated to reduce cocaine reward and cocaine seeking mainly through activation of antagonistic allosteric A2AR‐dopamine D2R (D2R) interactions in A2AR‐D2R heteroreceptor complexes. Furthermore, it was shown that modulation… read more here.
Keywords: d2r; accumbens shell; heteroreceptor complexes; a2ar d2r ... See more keywords
Chronic cocaine causes age-dependent increases in risky choice in both males and females.
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DOI: 10.1037/bne0000509
Abstract: Individuals who use cocaine exhibit maladaptive decision-making, overweighting rewards, and underweighting potential risks. We previously showed that chronic cocaine self-administration in young adult male rats causes long-lasting increases in risk taking. The present study expanded… read more here.
Keywords: cocaine self; administration; risk taking; chronic cocaine ... See more keywords
Prior Exposure to Alcohol Has No Effect on Cocaine Self-Administration and Relapse in Rats: Evidence from a Rat Model that Does Not Support the Gateway Hypothesis
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DOI: 10.1038/npp.2016.209
Abstract: The gateway hypothesis posits that initial exposure to legal drugs promotes subsequent addiction to illicit drugs. However, epidemiological studies are correlational and cannot rule out the alternative hypothesis of shared addiction vulnerability to legal and… read more here.
Keywords: self administration; exposure; cocaine; alcohol ... See more keywords
Role of neuropeptide neuromedin U in the nucleus accumbens shell in cocaine self-administration in male rats
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DOI: 10.1038/s41386-021-01234-9
Abstract: The nucleus accumbens shell (NAcSh) and its afferent and efferent neuronal projections control key aspects of motivation for cocaine. A recently described regulator of γ-aminobutyric acid (GABA) projections from the dorsal raphe nucleus (DRN) to… read more here.
Keywords: cocaine self; neuropeptide neuromedin; accumbens shell; administration ... See more keywords
Adolescent cannabinoid exposure induces irritability-like behavior and cocaine cross-sensitization without affecting the escalation of cocaine self-administration in adulthood
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DOI: 10.1038/s41598-018-31921-5
Abstract: Cannabis use is typically initiated during adolescence and is a significant risk factor for the development of cocaine use in adulthood. However, no preclinical studies have examined the effects of adolescent cannabinoid exposure on cocaine… read more here.
Keywords: like behavior; exposure; cocaine; irritability like ... See more keywords
Intermittent cocaine self-administration has sex-specific effects on addiction-like behaviors in rats
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1101/2022.12.19.521063
Abstract: Intermittent access (IntA) models of cocaine self-administration were developed to better model in rodents how cocaine is used by human drug users. Compared to traditional continuous access (ContA) models, IntA has been shown to enhance… read more here.
Keywords: cocaine self; self administration; cue; inta ... See more keywords