Ameliorative effect of taxifolin on gentamicin-induced ototoxicity via down-regulation of apoptotic pathways in mouse cochlear UB/OC-2 cells
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DOI: 10.1097/jcma.0000000000000708
Abstract: Background: Taxifolin is a flavanonol with efficacious cytoprotective properties, such as anti-inflammatory, antioxidant, anticancer, hepatoprotective, and nephroprotective effects. However, the potential protective effects of taxifolin against gentamicin-induced ototoxicity have not been confirmed. In this study,… read more here.
Keywords: gentamicin induced; taxifolin gentamicin; taxifolin; cochlear cells ... See more keywords
Bisdemethoxycurcumin-mediated Attenuation of Apoptosis Prevents Gentamicin-induced Ototoxicity in Mouse Cochlear UB/OC-2 Cells
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DOI: 10.21873/invivo.12807
Abstract: Background/Aim: Gentamicin has been widely prescribed since the last two decades despite its ototoxicity and nephrotoxicity. Bisdemethoxycurcumin (BDMC) is an affordable and safe curcuminoid with medicinal properties. We aimed to understand the effects of BDMC… read more here.
Keywords: cochlear cells; apoptosis; mouse cochlear; ototoxicity ... See more keywords