Peroxisome Deficiency in Cochlear Hair Cells Causes Hearing Loss by Deregulating BK Channels.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced science"
DOI: 10.1002/advs.202300402
Abstract: The peroxisome is a ubiquitous organelle in rodent cells and plays important roles in a variety of cell types and tissues. It is previously indicated that peroxisomes are associated with auditory function, and patients with… read more here.
Keywords: peroxisome deficiency; atoh1 pex5; cochlear hair; hair cells ... See more keywords
Cochlear hair cell regeneration after noise-induced hearing loss: Does regeneration follow development?
Sign Up to like & getrecommendations! Published in 2017 at "Hearing Research"
DOI: 10.1016/j.heares.2016.12.011
Abstract: Noise-induced hearing loss (NIHL) affects a large number of military personnel and civilians. Regenerating inner-ear cochlear hair cells (HCs) is a promising strategy to restore hearing after NIHL. In this review, we first summarize recent… read more here.
Keywords: hearing loss; regeneration; induced hearing; cochlear hair ... See more keywords
ATP depletion induced cochlear hair cells death through histone deacetylation in vitro
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience Letters"
DOI: 10.1016/j.neulet.2020.134918
Abstract: Previous studies have shown histone modifications being present in cochlear hair cells in animal models of hearing loss. Our past studies have shown that ATP depletion, histone deacetylase (HDAC) upregulation, and histone deacetylation occur in… read more here.
Keywords: hair cells; hair; cochlear hair; histone ... See more keywords
Netrin 1 mediates protective effects exerted by insulin-like growth factor 1 on cochlear hair cells
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.03.032
Abstract: ABSTRACT Sensorineural hearing loss (SNHL) is mainly caused by the damage of cochlear hair cells (HCs). As HCs and supporting cells (SCs) do not proliferate in postnatal mammals, the loss of HCs and SCs is… read more here.
Keywords: hair cells; hair; insulin like; igf1 ... See more keywords
The Kinocilia of Cochlear Hair Cells: Structures, Functions, and Diseases
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DOI: 10.3389/fcell.2021.715037
Abstract: Primary cilia are evolutionarily conserved and highly specialized organelles that protrude from cell membranes. Mutations in genes encoding ciliary proteins can cause structural and functional ciliary defects and consequently multiple diseases, collectively termed ciliopathies. The… read more here.
Keywords: hair cells; hair; kinocilia cochlear; cells structures ... See more keywords
An Antioxidant Screen Identifies Candidates for Protection of Cochlear Hair Cells from Gentamicin Toxicity
Sign Up to like & getrecommendations! Published in 2017 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2017.00242
Abstract: Reactive oxygen species are important elements in ototoxic damage to hair cells (HCs), appearing early in the damage process. Higher levels of natural antioxidants are positively correlated with resistance to ototoxins and many studies have… read more here.
Keywords: protection; hcs; hair cells; hair ... See more keywords