Translational issues in cochlear synaptopathy
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DOI: 10.1016/j.heares.2016.12.010
Abstract: ABSTRACT Understanding the biology of the previously underappreciated sensitivity of cochlear synapses to noise insult, and its clinical consequences, is becoming a mission for a growing number of auditory researchers. In addition, several research groups… read more here.
Keywords: translational issues; pathology; biology; cochlear synaptopathy ... See more keywords
Model-based hearing-enhancement strategies for cochlear synaptopathy pathologies
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DOI: 10.1101/2022.01.10.475652
Abstract: It is well known that ageing and noise exposure are important causes of sensorineural hearing loss, and can result in damage of the outer hair cells or other structures of the inner ear, including synaptic… read more here.
Keywords: hearing; hearing enhancement; enhancement strategies; based hearing ... See more keywords
Resource sharing in a collaborative study on cochlear synaptopathy and suprathreshold-hearing deficits
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DOI: 10.1121/1.4987812
Abstract: Evidence from animal models of substantial noise-induced cochlear synaptopathy even in the absence of measurable audiometric changes has led to an active debate over whether such damage occurs in humans, and whether it contributes to… read more here.
Keywords: hearing deficits; sharing collaborative; suprathreshold hearing; cochlear synaptopathy ... See more keywords
Suprathreshold hearing in middle age and relationship to cochlear synaptopathy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Acoustical Society of America"
DOI: 10.1121/1.5068320
Abstract: Animal models have demonstrated that the afferent synapses and nerve terminals innervating the cochlea are vulnerable to damage from acoustic overexposure and aging. This synaptopathy can occur without hair-cell loss, or more severely when accompanied… read more here.
Keywords: age; perceptual measures; middle age; cochlear synaptopathy ... See more keywords
Reliability and interrelations of seven proxy measures of cochlear synaptopathy
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the Acoustical Society of America"
DOI: 10.1121/1.5068469
Abstract: Investigations of cochlear synaptopathy in living humans rely on proxy measures of auditory nerve function. Numerous procedures have been developed, typically based on the auditory brainstem response (ABR), envelope-following response (EFR), or middle-ear muscle reflex… read more here.
Keywords: response; proxy measures; measures cochlear; abr wave ... See more keywords
Cochlear Synaptopathy: A Primary Factor Affecting Speech Recognition Performance in Presbycusis
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DOI: 10.1155/2021/6667531
Abstract: The results of recent animal studies have suggested that cochlear synaptopathy may be an important factor involved in presbycusis. Therefore, here, we aimed to examine whether cochlear synaptopathy frequently exists in patients with presbycusis and… read more here.
Keywords: factor; performance; speech recognition; cochlear synaptopathy ... See more keywords
Loud Music Exposure and Cochlear Synaptopathy in Young Adults: Isolated Auditory Brainstem Response Effects but No Perceptual Consequences
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DOI: 10.1177/2331216517737417
Abstract: The purpose of this study was to test the hypothesis that listeners with frequent exposure to loud music exhibit deficits in suprathreshold auditory performance consistent with cochlear synaptopathy. Young adults with normal audiograms were recruited… read more here.
Keywords: cochlear synaptopathy; loud music; exposure; auditory brainstem ... See more keywords
Categorization of tinnitus listeners with a focus on cochlear synaptopathy
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DOI: 10.1371/journal.pone.0277023
Abstract: Tinnitus is a complex and not yet fully understood phenomenon. Often the treatments provided are effective only for subgroups of sufferers. We are presently not able to predict benefit with the currently available diagnostic tools… read more here.
Keywords: focus cochlear; cochlear synaptopathy; tinnitus; tinnitus listeners ... See more keywords
Metabotropic glutamate receptor: A new possible therapeutic target for cochlear synaptopathy
Sign Up to like & getrecommendations! Published in 2022 at "Iranian Journal of Basic Medical Sciences"
DOI: 10.22038/ijbms.2021.59970.13296
Abstract: Objective(s): Cochlear synaptopathy is a common cause of auditory disorders in which glutamate over-activation occurs. Modulating glutamatergic pathways has been proposed to down-regulate post-synaptic excitation. Materials and Methods: 12-guinea pigs as sham and test groups… read more here.
Keywords: pre post; microscopy; cochlear synaptopathy; post ... See more keywords
Detecting Cochlear Synaptopathy Through Curvature Quantification of the Auditory Brainstem Response
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.851500
Abstract: The sound-evoked electrical compound potential known as auditory brainstem response (ABR) represents the firing of a heterogenous population of auditory neurons in response to sound stimuli, and is often used for clinical diagnosis based on… read more here.
Keywords: response; quantification; cochlear synaptopathy; abr ... See more keywords