Interaction of cochlin and mechanosensitive channel TREK-1 in trabecular meshwork cells influences the regulation of intraocular pressure
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DOI: 10.1038/s41598-017-00430-2
Abstract: In the eye, intraocular pressure (IOP) is tightly regulated and its persistent increase leads to ocular hypertension and glaucoma. We have previously shown that trabecular meshwork (TM) cells might detect aqueous humor fluid shear stress… read more here.
Keywords: intraocular pressure; trabecular meshwork; meshwork cells; trek ... See more keywords
Construction of mouse cochlin mutants with different GAG-binding specificities and their use for immunohistochemistry
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DOI: 10.1042/bcj20220339
Abstract: Glycosaminoglycan (GAG) is a polysaccharide present on the cell surface as an extracellular matrix component, and is composed of repeating disaccharide units consisting of an amino sugar and uronic acid except in the case of… read more here.
Keywords: cochlin; construction mouse; sulfated gags; mouse cochlin ... See more keywords
Involvement of cochlin binding to sulfated heparan sulfate/heparin in the pathophysiology of autosomal dominant late-onset hearing loss (DFNA9)
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DOI: 10.1371/journal.pone.0268485
Abstract: Late-onset non-syndromic autosomal dominant hearing loss 9 (DFNA9) is a hearing impairment caused by mutations in the coagulation factor C homology gene (COCH). COCH encodes for cochlin, a major component of the cochlear extracellular matrix.… read more here.
Keywords: cochlin; hearing loss; autosomal dominant; loss dfna9 ... See more keywords