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   Articles with "cocrystal" as a keyword



Reversible Thermosalience at Near-Human Body Temperature: A Novel Photothermally Actuated Mechanically Compliant Cocrystal.

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recommendations! Published in 2025 at "Small"

DOI: 10.1002/smll.202504196

Abstract: Dynamic crystals, characterized by their rapid response speed, diverse response forms, and lightweight, have emerged as promising material platforms for developing next-generation adaptive devices. Herein, a thermosalient cocrystal is developed, which possesses both mechanical flexibility… read more here.

Keywords: near human; body temperature; photothermally actuated; human body ... See more keywords

Selective formation of luminescent chiral cocrystal: Molecular self-assembly of 2,2′-binaphthol and 2-(3-pyridyl)-1H-benzimidazole

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recommendations! Published in 2017 at "Chinese Chemical Letters"

DOI: 10.1016/j.cclet.2017.12.021

Abstract: Abstract Luminescent cocrystals have been received much attention in fluorescence imaging and sensor application. In this work, we report that the high-quality chiral luminescent cocrystal can be obtained through a molecular self-assembly process of 2,2′-binaphthol… read more here.

Keywords: self assembly; pyridyl benzimidazole; cocrystal; binaphthol pyridyl ... See more keywords

Novel pharmaceutical cocrystal of lenalidomide with nicotinamide: Structural design, evaluation, and thermal phase transition study.

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recommendations! Published in 2021 at "International journal of pharmaceutics"

DOI: 10.1016/j.ijpharm.2021.121394

Abstract: Lenalidomide (LDM), widely used for the treatment of transfusion-dependent anaemia, has low oral bioavailability due to its poor aqueous solubility. Herein, we selected nicotinamide (NIC) as a coformer and synthesized a novel pharmaceutical cocrystal: lenalidomide-nicotinamide… read more here.

Keywords: pharmaceutical cocrystal; novel pharmaceutical; phase transition; cocrystal lenalidomide ... See more keywords
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Screening and structural elucidation of the zwitterionic cocrystal o-picolinic acid with p-nitro aniline

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recommendations! Published in 2017 at "Journal of Molecular Structure"

DOI: 10.1016/j.molstruc.2016.12.085

Abstract: Abstract The cocrystal was screened by solvent drop grinding method and the crystals were grown by slow evaporation method at ambient conditions. The cocrystal formation of o-picolinic acid with p-nitro aniline was initially analysed by… read more here.

Keywords: screening structural; cocrystal; nitro aniline; acid nitro ... See more keywords

A cocrystal for effectively reducing the hepatotoxicity of ethionamide

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recommendations! Published in 2021 at "Journal of Molecular Structure"

DOI: 10.1016/j.molstruc.2021.130729

Abstract: Abstract Although ethionamide (ETH) has proven highly effective for multidrug-resistant tuberculosis treatment, the severe hepatotoxicity limits the clinical application of ETH, making it still just a second-line drug to cure critical TB patients. In this paper, a… read more here.

Keywords: bai cocrystal; toxicity; cocrystal; hepatotoxicity ... See more keywords

Cocrystal of phloretin with isoniazid: preparation, characterization, and evaluation

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recommendations! Published in 2023 at "RSC Advances"

DOI: 10.1039/d3ra00750b

Abstract: Phloretin (Phl) is a natural flavonoid compound with wide range of biological activities but demonstrates poor water solubility and limited pharmacological effects. In this study, one cocrystal of phloretin–isoniazid (Phl–Inz) was prepared successfully using the… read more here.

Keywords: preparation characterization; phloretin; cocrystal; isoniazid preparation ... See more keywords

A Multicomponent Crystal Approach with Increased Permeability of Cocrystal of Emtricitabine with Zwitterionic L-Proline

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recommendations! Published in 2025 at "CrystEngComm"

DOI: 10.1039/d5ce00215j

Abstract: This investigation reports the synthesis and structural characterization of a zwitterionic cocrystal comprising anti-retroviral Emtricitabine (ECB) and L-proline (PRL), explicitly designed to enhance intestinal permeability. The cocrystal was synthesized via... read more here.

Keywords: permeability cocrystal; proline; emtricitabine; multicomponent crystal ... See more keywords

Novel dapagliflozin di-L-proline cocrystal-loaded tablet: preparation, physicochemical characterization, and pharmacokinetics in beagle dogs and mini-pigs

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recommendations! Published in 2022 at "Pharmaceutical Development and Technology"

DOI: 10.1080/10837450.2022.2052320

Abstract: Abstract Dapagliflozin base and a commercial dapagliflozin propanediol hydrate cocrystal (DPF-PDHC) were highly hygroscopic and thermally unstable. In this study, to address this limitation, we prepared a novel dapagliflozin di-L-proline cocrystal (DPF-LPC) and evaluated its… read more here.

Keywords: cocrystal; loaded tablet; dpf; dpf lpc ... See more keywords

Stoichiomorphic Halogen-Bonded Cocrystals. A Case Study of 1,4-Diiodotetrafluorobenzene and 3-Nitropyridine

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recommendations! Published in 2021 at "Canadian Journal of Chemistry"

DOI: 10.1139/cjc-2021-0245

Abstract: The concept of variable stoichiometry cocrystallization is explored in halogen-bonded systems. Three novel cocrystals of 1,4-diiodotetrafluorobenzene and 3-nitropyridine with molar ratios of 1:1, 2:1, and 1:2, respectively, are prepared by slow evaporation methods. Single-crystal X-ray… read more here.

Keywords: halogen bonded; cocrystal; diiodotetrafluorobenzene nitropyridine; halogen ... See more keywords