Selective formation of luminescent chiral cocrystal: Molecular self-assembly of 2,2′-binaphthol and 2-(3-pyridyl)-1H-benzimidazole
Sign Up to like & getrecommendations! Published in 2017 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2017.12.021
Abstract: Abstract Luminescent cocrystals have been received much attention in fluorescence imaging and sensor application. In this work, we report that the high-quality chiral luminescent cocrystal can be obtained through a molecular self-assembly process of 2,2′-binaphthol… read more here.
Keywords: self assembly; pyridyl benzimidazole; cocrystal; binaphthol pyridyl ... See more keywords
Novel pharmaceutical cocrystal of lenalidomide with nicotinamide: Structural design, evaluation, and thermal phase transition study.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of pharmaceutics"
DOI: 10.1016/j.ijpharm.2021.121394
Abstract: Lenalidomide (LDM), widely used for the treatment of transfusion-dependent anaemia, has low oral bioavailability due to its poor aqueous solubility. Herein, we selected nicotinamide (NIC) as a coformer and synthesized a novel pharmaceutical cocrystal: lenalidomide-nicotinamide… read more here.
Keywords: pharmaceutical cocrystal; novel pharmaceutical; phase transition; cocrystal lenalidomide ... See more keywords
Screening and structural elucidation of the zwitterionic cocrystal o-picolinic acid with p-nitro aniline
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2016.12.085
Abstract: Abstract The cocrystal was screened by solvent drop grinding method and the crystals were grown by slow evaporation method at ambient conditions. The cocrystal formation of o-picolinic acid with p-nitro aniline was initially analysed by… read more here.
Keywords: screening structural; cocrystal; nitro aniline; acid nitro ... See more keywords
A cocrystal for effectively reducing the hepatotoxicity of ethionamide
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2021.130729
Abstract: Abstract Although ethionamide (ETH) has proven highly effective for multidrug-resistant tuberculosis treatment, the severe hepatotoxicity limits the clinical application of ETH, making it still just a second-line drug to cure critical TB patients. In this paper, a… read more here.
Keywords: bai cocrystal; toxicity; cocrystal; hepatotoxicity ... See more keywords
Cocrystal of phloretin with isoniazid: preparation, characterization, and evaluation
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DOI: 10.1039/d3ra00750b
Abstract: Phloretin (Phl) is a natural flavonoid compound with wide range of biological activities but demonstrates poor water solubility and limited pharmacological effects. In this study, one cocrystal of phloretin–isoniazid (Phl–Inz) was prepared successfully using the… read more here.
Keywords: preparation characterization; phloretin; cocrystal; isoniazid preparation ... See more keywords
Novel dapagliflozin di-L-proline cocrystal-loaded tablet: preparation, physicochemical characterization, and pharmacokinetics in beagle dogs and mini-pigs
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutical Development and Technology"
DOI: 10.1080/10837450.2022.2052320
Abstract: Abstract Dapagliflozin base and a commercial dapagliflozin propanediol hydrate cocrystal (DPF-PDHC) were highly hygroscopic and thermally unstable. In this study, to address this limitation, we prepared a novel dapagliflozin di-L-proline cocrystal (DPF-LPC) and evaluated its… read more here.
Keywords: cocrystal; loaded tablet; dpf; dpf lpc ... See more keywords
Stoichiomorphic Halogen-Bonded Cocrystals. A Case Study of 1,4-Diiodotetrafluorobenzene and 3-Nitropyridine
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DOI: 10.1139/cjc-2021-0245
Abstract: The concept of variable stoichiometry cocrystallization is explored in halogen-bonded systems. Three novel cocrystals of 1,4-diiodotetrafluorobenzene and 3-nitropyridine with molar ratios of 1:1, 2:1, and 1:2, respectively, are prepared by slow evaporation methods. Single-crystal X-ray… read more here.
Keywords: halogen bonded; cocrystal; diiodotetrafluorobenzene nitropyridine; halogen ... See more keywords