Articles with "cocrystal dissolution" as a keyword



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In Vitro-In Vivo Correlation in Cocrystal Dissolution: Consideration of Drug Release Profiles Based on Coformer Dissolution and Absorption Behavior.

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Published in 2021 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.1c00537

Abstract: This study assessed the in vitro-in vivo correlation in cocrystal dissolution based on the coformer behavior. 4-Aminobenzoic acid (4ABA) was used as a coformer. Cocrystals of poorly water-soluble drugs with 4ABA, ketoconazole cocrystal (KTZ-4ABA), posaconazole… read more here.

Keywords: cocrystal dissolution; vitro vivo; based coformer; ktz 4aba ... See more keywords
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Synchronization of Cocrystal Dissolution and Drug Precipitation to Sustain Drug Supersaturation.

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Published in 2022 at "Molecular pharmaceutics"

DOI: 10.1021/acs.molpharmaceut.2c00122

Abstract: A graphical analysis of both drug and coformer concentrations contributed by dissolving cocrystals is presented in the context of a simplified cocrystal phase diagram. The conceptual basis and analysis identify parameters that control cocrystal dissolution-drug… read more here.

Keywords: dissolution drug; drug supersaturation; drug; cocrystal dissolution ... See more keywords