Novel pharmaceutical cocrystal of lenalidomide with nicotinamide: Structural design, evaluation, and thermal phase transition study.
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DOI: 10.1016/j.ijpharm.2021.121394
Abstract: Lenalidomide (LDM), widely used for the treatment of transfusion-dependent anaemia, has low oral bioavailability due to its poor aqueous solubility. Herein, we selected nicotinamide (NIC) as a coformer and synthesized a novel pharmaceutical cocrystal: lenalidomide-nicotinamide… read more here.
Keywords: pharmaceutical cocrystal; novel pharmaceutical; phase transition; cocrystal lenalidomide ... See more keywords