Structure determination and Hirshfeld surface analysis of new cocrystal and salt forms of 5-aminotetrazole with hydroxy- and nitro-substituted carboxylic acids.
Sign Up to like & getrecommendations! Published in 2022 at "Acta crystallographica. Section C, Structural chemistry"
DOI: 10.1107/s2053229622006519
Abstract: Two new crystalline solids, namely, 5-aminotetrazole-3,5-dihydroxybenzoic acid-water (1/4/6), CH3N5·4C7H6O4·6H2O (I), and 5-aminotetrazolium 3,5-dinitrosalicylate, CH4N5+·C7H3N2O7- (II), have been synthesized and characterized by single-crystal X-ray diffraction and Hirshfeld surface analysis. The crystal packing arrangements of I and… read more here.
Keywords: surface analysis; cocrystal salt; hirshfeld surface;
Levofloxacin Cocrystal/Salt with Phthalimide and Caffeic Acid as Promising Solid-State Approach to Improve Antimicrobial Efficiency
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DOI: 10.3390/antibiotics11060797
Abstract: To overcome the issue of multidrug resistant (MDR) microbes, the exploration of ways to improve the antimicrobial efficiency of existing antibiotics is one of the promising approaches. In search of synthons with higher efficiency, in… read more here.
Keywords: antimicrobial efficiency; improve antimicrobial; efficiency; cocrystal salt ... See more keywords
Simultaneous Improvement of Dissolution Behavior and Oral Bioavailability of Antifungal Miconazole via Cocrystal and Salt Formation
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DOI: 10.3390/pharmaceutics14051107
Abstract: Miconazole shows low oral bioavailability in humans due to poor aqueous solubility, although it has demonstrated various pharmacological activities such as antifungal, anti-tubercular and anti-tumor effects. Cocrystal/salt formation is one of the effective methods for… read more here.
Keywords: formation; oral bioavailability; cocrystal salt; miconazole ... See more keywords
Insight into the Formation of Cocrystal and Salt of Tenoxicam from the Isomer and Conformation
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DOI: 10.3390/pharmaceutics14091968
Abstract: Tenoxicam (TNX) is a new non-steroidal anti-inflammatory drug that shows a superior anti-inflammatory effect and has the advantages of a long half-life period, a fast onset of action, a small dose, complete metabolism, and good… read more here.
Keywords: insight formation; tnx; cocrystals salt; cocrystal salt ... See more keywords