Structures of β-klotho reveal a ‘zip code’-like mechanism for endocrine FGF signalling
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DOI: 10.1038/nature25010
Abstract: Canonical fibroblast growth factors (FGFs) activate FGF receptors (FGFRs) through paracrine or autocrine mechanisms in a process that requires cooperation with heparan sulfate proteoglycans, which function as co-receptors for FGFR activation. By contrast, endocrine FGFs… read more here.
Keywords: fgf; mechanism; zip code; fgf21 ... See more keywords