Vomiting and constipation associated with tramadol and codeine: a comparative study in VigiBase®
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Clinical Pharmacology"
DOI: 10.1007/s00228-018-2536-z
Abstract: The most frequent adverse drug reactions (ADRs) of codeine and tramadol, the two main step 2 opioid analgesics, include nausea, dizziness, sedation, vomiting, and constipation [1]. The relative importance of vomiting and constipation remains discussed… read more here.
Keywords: codeine; tramadol; vigibase; study ... See more keywords
Codeine-induced hepatic injury is via oxido-inflammatory damage and caspase-3-mediated apoptosis.
Sign Up to like & getrecommendations! Published in 2020 at "Molecular biology reports"
DOI: 10.1007/s11033-020-05983-6
Abstract: Codeine (3-methylmorphine) is a known analgesic, antitussive, and antidiarrheal drug that is often abused for recreational purposes. It is metabolized in the liver via the cytochrome P450 system and thus hypothesized to induce hepatic injury… read more here.
Keywords: codeine; caspase; codeine induced; damage ... See more keywords
Pharmacists’ views on the upscheduling of codeine-containing analgesics to ‘prescription only’ medicines in Australia
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Clinical Pharmacy"
DOI: 10.1007/s11096-019-00804-8
Abstract: Background Codeine is the most commonly used opioid worldwide, and is available over-the-counter (OTC) in many countries. There is continual debate regarding the risk:benefit profile for OTC codeine. In Australia, codeine containing analgesics became ‘prescription… read more here.
Keywords: codeine; codeine upscheduling; codeine containing; community pharmacists ... See more keywords
Impact of Safety-Related Regulations on Codeine Use in Children: A Quasi-Experimental Study Using Taiwan’s National Health Insurance Research Database
Sign Up to like & getrecommendations! Published in 2017 at "Drug Safety"
DOI: 10.1007/s40264-017-0524-3
Abstract: IntroductionSafety concerns regarding potential life-threatening adverse events associated with codeine have resulted in policy decisions to restrict its use in pediatrics. However, whether these drug safety communications have had an immediate and strong impact on… read more here.
Keywords: codeine; related regulations; safety related; impact ... See more keywords
Characterization of the in vitro CYP450 mediated metabolism of the polymorphic CYP2D6 probe drug codeine in horses.
Sign Up to like & getrecommendations! Published in 2019 at "Biochemical pharmacology"
DOI: 10.1016/j.bcp.2019.07.005
Abstract: Despite their widespread popularity as sport and companion animals and published and anecdotal reports of vast difference in drug disposition and pharmacokinetics between individuals, studies describing equine drug metabolism are limited. It has been theorized… read more here.
Keywords: codeine; polymorphic cyp2d6; drug; mediated metabolism ... See more keywords
WITHDRAWN: Ratio of Morphine and Codeine over Antihistamines in Urine by LC-MS/MS for Determining Opiate Metabolites from Cold Syrups
Sign Up to like & getrecommendations! Published in 2020 at "Forensic Science International"
DOI: 10.1016/j.forsciint.2020.110172
Abstract: Abstract Determining the origin of opiate and/or opiate metabolites from cold syrups in individual urine specimens is vital for patients, doctors and law enforcement. Ten participants were orally administered cold syrups with three different formulations.… read more here.
Keywords: codeine; cold syrups; opiate metabolites; morphine codeine ... See more keywords
Formal Synthesis of (-)-Codeine by Application of Temporary Thio Derivatization.
Sign Up to like & getrecommendations! Published in 2018 at "Organic letters"
DOI: 10.1021/acs.orglett.7b03972
Abstract: Desymmetrization of a p-quinone monoacetal by organocatalytic sulfa-Michael addition provided rapid access to a C-ring building block for a formal synthesis of (-)-codeine. By means of a diastereoselective 1,2-addition for A/C-ring union, an intramolecular nitrone… read more here.
Keywords: codeine; formal synthesis; codeine application; synthesis codeine ... See more keywords
Extracorporeal elimination of butalbital in acute aspirin–butalbital–caffeine–codeine (Fiorinal with Codeine) poisoning
Sign Up to like & getrecommendations! Published in 2018 at "Clinical Toxicology"
DOI: 10.1080/15563650.2017.1400554
Abstract: Abstract Background: Butalbital is a small molecule (approximately 220 Da), with 26% protein binding, a 0.8 L/kg volume of distribution, and is eliminated nearly 80% unchanged in the urine. Although hemodialysis has been used to treat overdoses… read more here.
Keywords: codeine; elimination butalbital; fiorinal codeine; butalbital caffeine ... See more keywords
CYP2D6 Basic Genotyping of Patients with Chronic Pain Receiving Tramadol or Codeine. A Study in a Greek Cohort.
Sign Up to like & getrecommendations! Published in 2020 at "Pain medicine"
DOI: 10.1093/pm/pnaa122
Abstract: OBJECTIVE To assess CYP2D6 genotype prevalence in chronic pain patients treated with tramadol or codeine. DESIGN Prospective cohort study. SETTING General hospital, pain management unit. SUBJECTS Patients with chronic pain, treated with codeine or tramadol.… read more here.
Keywords: codeine; tramadol codeine; cyp2d6; chronic pain ... See more keywords
Assessment of sexual behaviour and fertility indices in male rabbits following chronic codeine use
Sign Up to like & getrecommendations! Published in 2019 at "Andrology"
DOI: 10.1111/andr.12717
Abstract: Codeine is the latest trend of drug abuse, particularly in Nigeria and regarded as the gateway to the abuse of other substances. read more here.
Keywords: codeine; assessment sexual; indices male; behaviour fertility ... See more keywords
Tramadol versus Codeine and the Short-term Risk of Cardiovascular Events in Patients with Non-Cancer Pain: A Population-Based Cohort Study.
Sign Up to like & getrecommendations! Published in 2021 at "British journal of clinical pharmacology"
DOI: 10.1111/bcp.15099
Abstract: AIM The effect of tramadol on the cardiovascular system is largely unknown. There is concern that, with its multimodal mechanism of action to increase serotonin and norepinephrine levels in the body, it could increase the… read more here.
Keywords: codeine; risk; patients non; non cancer ... See more keywords