Machine learning reveals multimodal MRI patterns predictive of isocitrate dehydrogenase and 1p/19q status in diffuse low- and high-grade gliomas
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Neuro-Oncology"
DOI: 10.1007/s11060-019-03096-0
Abstract: PurposeIsocitrate dehydrogenase (IDH) and 1p19q codeletion status are importantin providing prognostic information as well as prediction of treatment response in gliomas. Accurate determination of the IDH mutation status and 1p19q co-deletion prior to surgery may… read more here.
Keywords: status; dehydrogenase; machine learning; gliomas ... See more keywords
FISH analysis of brain smears obtained at intraoperative diagnosis – An accurate and fast method to detect 1p/19q-codeletion in gliomas
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Clinical Neuroscience"
DOI: 10.1016/j.jocn.2021.07.043
Abstract: The importance of molecular testing of gliomas is highlighted in the 2016 revised 4th edition of the WHO Classification of Tumours of the Central Nervous System, which applies an integrated diagnosis of histological and molecular… read more here.
Keywords: 19q codeletion; fish analysis; method; codeletion ... See more keywords
Role of 1p/19q Codeletion in Diffuse Low-grade Glioma Tumour Prognosis
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DOI: 10.21873/anticanres.16432
Abstract: Background/Aim: In the latest 2021 WHO classification of central nervous system tumours (CNS), gliomas that present isocitrate dehydrogenase (IDH) mutations are defined as diffuse low-grade gliomas (DLGGs). IDH mutations are commonly observed in this tumour… read more here.
Keywords: pfs months; 19q codeletion; codeletion; resection ... See more keywords
Prediction of IDH1-Mutation and 1p/19q-Codeletion Status Using Preoperative MR Imaging Phenotypes in Lower Grade Gliomas
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DOI: 10.3174/ajnr.a5421
Abstract: BACKGROUND AND PURPOSE: WHO grade II gliomas are divided into three classes: isocitrate dehydrogenase (IDH)-wildtype, IDH-mutant and no 1p/19q codeletion, and IDH-mutant and 1p/19q-codeleted. Different molecular subtypes have been reported to have prognostic differences and… read more here.
Keywords: codeletion; grade; idh1 mutation; lower grade ... See more keywords