Redox-Responsive and Drug-Embedded Silica Nanoparticles with Unique Self-Destruction Features for Efficient Gene/Drug Codelivery
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201606229
Abstract: The development of advanced gene/drug codelivery carriers with stimuli-responsive release manner for complementary cancer therapy is desirable. In this study, novel disulfide-bridged and doxorubicin (DOX)-embedded degradable silica nanoparticles (DS-DOX) with unique self-destruction features are synthesized… read more here.
Keywords: destruction; gene drug; drug; codelivery ... See more keywords
Multifunctional Glyco-Nanofibers: siRNA Induced Supermolecular Assembly for Codelivery In Vivo
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201703083
Abstract: Targeted codelivery and controlled release of drug/siRNA (small interfering RNA) in a safe and effective vehicle hold great promises for overcoming drug resistance and optimal efficacy in cancer treatment; however, rational design and preparation of… read more here.
Keywords: glyco nanofibers; supermolecular assembly; codelivery; vivo ... See more keywords
Near Infrared-Activatable Methylene Blue Polypeptide Codelivery of the NO Prodrug via π-π Stacking for Cascade Reactive Oxygen Species Amplification-Mediated Photodynamic Therapy.
Sign Up to like & getrecommendations! Published in 2023 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.2c21280
Abstract: The application of photodynamic therapy (PDT) has attracted remarkable interest in cancer treatment because of the advantages of noninvasiveness and spatiotemporal selectivity. However, the PDT efficiency is considerably limited by photosensitizer (PS) quenching and severe… read more here.
Keywords: methylene blue; near infrared; activatable methylene; codelivery ... See more keywords
Enhanced Lysosomal Escape of pH-Responsive Polyethylenimine-Betaine Functionalized Carbon Nanotube for the Codelivery of Survivin Small Interfering RNA and Doxorubicin.
Sign Up to like & getrecommendations! Published in 2019 at "ACS applied materials & interfaces"
DOI: 10.1021/acsami.8b20810
Abstract: The combination of gene therapy and chemotherapy has recently received considerable attention for cancer treatment. However, low transfection efficiency and poor endosomal escape of genes from nanocarriers strongly limit the success of the clinical use… read more here.
Keywords: escape; survivin; codelivery; dox ... See more keywords
A comprehensive review of protein-based carriers with simple structures for the co-encapsulation of bioactive agents.
Sign Up to like & getrecommendations! Published in 2023 at "Comprehensive reviews in food science and food safety"
DOI: 10.1111/1541-4337.13139
Abstract: The rational design and fabrication of edible codelivery carriers are important to develop functional foods fortified with a plurality of bioactive agents, which may produce synergistic effects in increasing bioactivity and functionality to target specific… read more here.
Keywords: multiple bioactive; based carriers; bioactive agents; carriers simple ... See more keywords
Nanodevices for the Efficient Codelivery of CRISPR-Cas9 Editing Machinery and an Entrapped Cargo: A Proposal for Dual Anti-Inflammatory Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14071495
Abstract: In this article, we report one of the few examples of nanoparticles capable of simultaneously delivering CRISPR-Cas9 gene-editing machinery and releasing drugs for one-shot treatments. Considering the complexity of inflammation in diseases, the synergistic effect… read more here.
Keywords: crispr cas9; crispr; therapy; codelivery ... See more keywords