Pathway and network analysis of more than 2500 whole cancer genomes
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-14367-0
Abstract: The catalog of cancer driver mutations in protein-coding genes has greatly expanded in the past decade. However, non-coding cancer driver mutations are less well-characterized and only a handful of recurrent non-coding mutations, most notably TERT… read more here.
Keywords: pathway network; analysis; non coding; coding mutations ... See more keywords
BayesPI-BAR2: A New Python Package for Predicting Functional Non-coding Mutations in Cancer Patient Cohorts
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2019.00282
Abstract: Most of somatic mutations in cancer occur outside of gene coding regions. These mutations may disrupt the gene regulation by affecting protein-DNA interaction. A study of these disruptions is important in understanding tumorigenesis. However, current… read more here.
Keywords: bayespi bar2; non coding; mutations cancer; coding mutations ... See more keywords
A Pipeline for Classifying Deleterious Coding Mutations in Agricultural Plants
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Plant Science"
DOI: 10.3389/fpls.2018.01734
Abstract: The impact of deleterious variation on both plant fitness and crop productivity is not completely understood and is a hot topic of debates. The deleterious mutations in plants have been solely predicted using sequence conservation… read more here.
Keywords: deleterious coding; pipeline classifying; classifying deleterious; deleterious mutations ... See more keywords