The Integrator complex at the crossroad of coding and noncoding RNA.
Sign Up to like & getrecommendations! Published in 2020 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2020.11.003
Abstract: Genomic transcription is fundamental to all organisms. In metazoans, the Integrator complex is required for endonucleolytic processing of noncoding RNAs, regulation of RNA polymerase II pause-release, and premature transcription attenuation at coding genes. Recent insights… read more here.
Keywords: complex crossroad; integrator complex; noncoding rna; crossroad coding ... See more keywords
Circular RNAs: Coding or noncoding?
Sign Up to like & getrecommendations! Published in 2017 at "Cell Research"
DOI: 10.1038/cr.2017.70
Abstract: Circular RNAs (circRNAs) were only recently discovered as a new class of noncoding RNAs, functionally still largely uncharacterized. Three publications that appeared concurrently in Cell Research and Molecular Cell provide initial evidence for certain endogenous… read more here.
Keywords: rnas coding; circular rnas; coding noncoding;
Top-down stepwise refinement identifies coding and noncoding RNA-associated epigenetic regulatory maps in malignant glioma.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cellular and molecular medicine"
DOI: 10.1111/jcmm.17244
Abstract: With the emergence of the molecular era and retreat of the histology epoch in malignant glioma, it is becoming increasingly necessary to research diagnostic/prognostic/therapeutic biomarkers and their related regulatory mechanisms. While accumulating studies have investigated… read more here.
Keywords: noncoding rna; rna associated; coding noncoding; malignant glioma ... See more keywords
Open reading frame dominance indicates protein‐coding potential of RNAs
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202154321
Abstract: Recent studies have identified numerous RNAs with both coding and noncoding functions. However, the sequence characteristics that determine this bifunctionality remain largely unknown. In the present study, we develop and test the open reading frame… read more here.
Keywords: coding noncoding; orf dominance; reading frame; dominance ... See more keywords
Characterization of Coding/Noncoding Variants for SHROOM3 in Patients with CKD.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of the American Society of Nephrology : JASN"
DOI: 10.1681/asn.2017080856
Abstract: Background Interpreting genetic variants is one of the greatest challenges impeding analysis of rapidly increasing volumes of genomic data from patients. For example, SHROOM3 is an associated risk gene for CKD, yet causative mechanism(s) of… read more here.
Keywords: noncoding variants; variants shroom3; characterization coding; ckd ... See more keywords
Effects of Ethanol on Expression of Coding and Noncoding RNAs in Murine Neuroblastoma Neuro2a Cells
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23137294
Abstract: Excessive use of alcohol can induce neurobiological and neuropathological alterations in the brain, including the hippocampus and forebrain, through changes in neurotransmitter systems, hormonal systems, and neuroimmune processes. We aimed to investigate the effects of… read more here.
Keywords: expression coding; coding noncoding; effects ethanol; expression ... See more keywords