Discovery and characterization of novel trans‐spliced products of human polyoma JC virus late transcripts from PML patients
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.26219
Abstract: Although the human neurotropic polyomavirus, JC virus (JCV), was isolated almost a half century ago, understanding the molecular mechanisms governing its biology remains highly elusive. JCV infects oligodendrocytes and astrocytes in the central nervous system… read more here.
Keywords: pml patients; spliced products; late transcripts; coding regions ... See more keywords
Novel RT-ddPCR assays for simultaneous quantification of multiple noncoding and coding regions of SARS-CoV-2 RNA
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Virological Methods"
DOI: 10.1016/j.jviromet.2021.114115
Abstract: A hallmark of coronavirus transcription is the generation of negative-sense RNA intermediates that serve as the templates for the synthesis of positive-sense genomic RNA (gRNA) and an array of subgenomic mRNAs (sgRNAs) encompassing sequences arising… read more here.
Keywords: ddpcr assays; assays simultaneous; coding regions; novel ddpcr ... See more keywords
Discovery of coding regions in the human genome by integrated proteogenomics analysis workflow
Sign Up to like & getrecommendations! Published in 2018 at "Nature Communications"
DOI: 10.1038/s41467-018-03311-y
Abstract: Proteogenomics enable the discovery of novel peptides (from unannotated genomic protein-coding loci) and single amino acid variant peptides (derived from single-nucleotide polymorphisms and mutations). Increasing the reliability of these identifications is crucial to ensure their… read more here.
Keywords: proteogenomics analysis; coding regions; integrated proteogenomics; discovery ... See more keywords
Ranking of non-coding pathogenic variants and putative essential regions of the human genome
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-13212-3
Abstract: A gene is considered essential if loss of function results in loss of viability, fitness or in disease. This concept is well established for coding genes; however, non-coding regions are thought less likely to be… read more here.
Keywords: ranking non; coding pathogenic; pathogenic variants; variants non ... See more keywords
End-to-end Learning Of Evolutionary Models To Find Coding Regions In Genome Alignments.
Sign Up to like & getrecommendations! Published in 2022 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btac028
Abstract: MOTIVATION The comparison of genomes using models of molecular evolution is a powerful approach for finding, or towards understanding, functional elements. In particular, comparative genomics is a fundamental building brick in annotating ever larger sets… read more here.
Keywords: end end; coding regions; learning evolutionary; end learning ... See more keywords
IEAtlas: an atlas of HLA-presented immune epitopes derived from non-coding regions
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac776
Abstract: Abstract Cancer-related epitopes can engage the immune system against tumor cells, thus exploring epitopes derived from non-coding regions is emerging as a fascinating field in cancer immunotherapies. Here, we described a database, IEAtlas (http://bio-bigdata.hrbmu.edu.cn/IEAtlas), which… read more here.
Keywords: derived non; hla presented; epitopes derived; coding regions ... See more keywords
Determinants of the regulation of Helicobacter pylori adhesins include repeat sequences in both promoter and coding regions as well as the two‐component system ArsRS
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Medical Microbiology"
DOI: 10.1099/jmm.0.000491
Abstract: Purpose. We investigated the transcription of adhesin‐encoding genes sabA, hopZ and labA in Helicobacter pylori strain J99. Each possesses a repeating homopolymeric nucleotide tract within their promoter regions, and sabA and hopZ possess repeats within… read more here.
Keywords: coding regions; pylori; promoter; helicobacter pylori ... See more keywords
Characterisation of the complete mitochondrial genome of the insect-parasitic nematode Heterorhabditis bacteriophora: an idiosyncratic gene order and the presence of multiple long non-coding regions
Sign Up to like & getrecommendations! Published in 2021 at "Nematology"
DOI: 10.1163/15685411-bja10110
Abstract: We present here the complete mtDNA genome (mitogenome) of Heterorhabditis bacteriophora, an important biological control agent of soil-dwelling insect pests in agriculture and horticulture. This is the first description of a mitogenome for a member… read more here.
Keywords: coding regions; non coding; heterorhabditis bacteriophora; genome ... See more keywords
An integrative approach to predicting the functional effects of small indels in non-coding regions of the human genome
Sign Up to like & getrecommendations! Published in 2017 at "BMC Bioinformatics"
DOI: 10.1186/s12859-017-1862-y
Abstract: BackgroundSmall insertions and deletions (indels) have a significant influence in human disease and, in terms of frequency, they are second only to single nucleotide variants as pathogenic mutations. As the majority of mutations associated with… read more here.
Keywords: regions human; coding regions; human genome; indels non ... See more keywords
SLC26A4-linked CEVA haplotype correlates with phenotype in patients with enlargement of the vestibular aqueduct
Sign Up to like & getrecommendations! Published in 2019 at "BMC Medical Genetics"
DOI: 10.1186/s12881-019-0853-4
Abstract: BackgroundRecessive mutations of coding regions and splice sites of the SLC26A4 gene cause hearing loss with enlargement of the vestibular aqueduct (EVA). Some patients also have a thyroid iodination defect that can lead to multinodular… read more here.
Keywords: regions splice; splice sites; mutations affecting; coding regions ... See more keywords
Positive selection in coding regions and motif duplication in regulatory regions of bottlenose dolphin MHC class II genes
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DOI: 10.1371/journal.pone.0203450
Abstract: The vertebrate immune response is mediated through highly adaptive, quickly evolving cell surface receptors, the major histocompatibility complex (MHC). MHC molecules bind and present a diverse array of pathogenic molecules and trigger a cascade of… read more here.
Keywords: coding regions; selection; dqa dqb; mhc ... See more keywords