Stable recombinant production of codon‐scrambled lubricin and mucin in human cells
Sign Up to like & getrecommendations! Published in 2019 at "Biotechnology and Bioengineering"
DOI: 10.1002/bit.26940
Abstract: Widespread therapeutic and commercial interest in recombinant mucin technology has emerged due to the unique ability of mucin glycoproteins to hydrate, protect, and lubricate biological surfaces. However, recombinant production of the large, highly repetitive domains… read more here.
Keywords: production; mucin; recombinant production; stable recombinant ... See more keywords
Two‐Tier Screening Platform for Directed Evolution of Aminoacyl–tRNA Synthetases with Enhanced Stop Codon Suppression Efficiency
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700039
Abstract: Genetic code expansion through amber stop codon suppression provides a powerful tool for introducing non‐proteinogenic functionalities into proteins for a broad range of applications. However, ribosomal incorporation of noncanonical amino acids (ncAAs) by means of… read more here.
Keywords: stop codon; platform; codon; efficiency ... See more keywords
Comparative genomic analysis for nucleotide, codon, and amino acid usage patterns of mycoplasmas
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Basic Microbiology"
DOI: 10.1002/jobm.201700490
Abstract: The evolutionary factors in influencing the genetic characteristics of nucleotide, synonymous codon, and amino acid usage of 18 mycoplasma species were analyzed. The nucleotide usage at the 1st and 2nd codon position which determines amino… read more here.
Keywords: amino acid; nucleotide usage; acid usage; codon ... See more keywords
A derived Polymorphic Amplified Cleaved Sequence (dPACS) assay for detecting the Δ210 PPX2L codon deletion conferring target-site resistance to protoporphyrinogen oxidase (PPO)-inhibiting herbicides.
Sign Up to like & getrecommendations! Published in 2019 at "Pest management science"
DOI: 10.1002/ps.5581
Abstract: BACKGROUND Resistance to protoporphyrinogen oxidase (PPO)-inhibiting herbicides in Amaranthus rudis from corn/soybean production systems in the USA appears to be mainly due to a codon deletion at position 210 of the target PPX2L gene. In… read more here.
Keywords: codon deletion; resistance; inhibiting herbicides; codon ... See more keywords
Artificial Division of Codon Boxes for Expansion of the Amino Acid Repertoire of Ribosomal Polypeptide Synthesis.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7574-7_2
Abstract: In ribosomal polypeptide synthesis, the 61 sense codons redundantly code for the 20 proteinogenic amino acids. The genetic code contains eight family codon boxes consisting of synonymous codons that redundantly code for the same amino… read more here.
Keywords: amino; amino acids; ribosomal polypeptide; codon boxes ... See more keywords
The impracticalities of multiplicatively-closed codon models: a retreat to linear alternatives.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of mathematical biology"
DOI: 10.1007/s00285-020-01519-5
Abstract: A matrix Lie algebra is a linear space of matrices closed under the operation [Formula: see text]. The "Lie closure" of a set of matrices is the smallest matrix Lie algebra which contains the set.… read more here.
Keywords: closure; codon models; matrix; codon ... See more keywords
Overexpressing codon-adapted fusion proteins of 4-coumaroyl-CoA ligase (4CL) and stilbene synthase (STS) for resveratrol production in Chlamydomonas reinhardtii
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Phycology"
DOI: 10.1007/s10811-020-02123-2
Abstract: Resveratrol is a plant phenolic secondary metabolite derived from phenylpropane metabolic pathway. It is a phytoalexin of high pharmaceutical interest produced in the defense response of plants. To produce resveratrol in Chlamydomonas reinhardtii, 4-coumaroyl-CoA ligase… read more here.
Keywords: coa ligase; resveratrol; ligase 4cl; coumaroyl coa ... See more keywords
Essentiality, conservation, evolutionary pressure and codon bias in bacterial genomes.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.04.017
Abstract: Essential genes constitute the core of genes which cannot be mutated too much nor lost along the evolutionary history of a species. Natural selection is expected to be stricter on essential genes and on conserved… read more here.
Keywords: essential genes; essentiality conservation; codon bias; conservation ... See more keywords
Spontaneous evolution of circular codes in theoretical minimal RNA rings.
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DOI: 10.1016/j.gene.2019.03.069
Abstract: Small circular RNAs occur in many cells. Theoretical considerations designed to mimick primordial RNAs designed 25 theoretical, minimal 22-nucleotide long circular RNAs (RNA rings) forming stem-loop hairpins, including one codon per amino acid, a start… read more here.
Keywords: rna rings; amino acid; code; codon ... See more keywords
The impact of codon choice on translation process in Saccharomyces cerevisiae: folding class, protein function and secondary structure.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of theoretical biology"
DOI: 10.1016/j.jtbi.2021.110806
Abstract: The genetic code consists in a set of rules used by living organisms to translate genomic information, contained in genes, into proteins; every amino acid is coded by a set of nucleotide triplets or codons.… read more here.
Keywords: codon choice; process; translation; choice ... See more keywords
Extensive genomic recoding by codon-pair deoptimization selective for mammals is a flexible tool to generate attenuated vaccine candidates for dengue virus 2.
Sign Up to like & getrecommendations! Published in 2019 at "Virology"
DOI: 10.1016/j.virol.2019.09.003
Abstract: The four serotypes of dengue virus (DENV) are the leading etiologic agent of disease caused by arthropod-borne viruses (arboviruses) in the world, with billions at risk of DENV infection spread by infected mosquitoes. DENV causes… read more here.
Keywords: codon; codon pair; dengue virus; vaccine candidates ... See more keywords