Attenuated Codon Optimality Contributes to Neural-Specific mRNA Decay in Drosophila
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.07.039
Abstract: SUMMARY Tissue-specific mRNA stability is important for cell fate and physiology, but the mechanisms involved are not fully understood. We found that zygotic mRNA stability in Drosophila correlates with codon content: optimal codons are enriched… read more here.
Keywords: optimal codons; nervous system; specific mrna; codon optimality ... See more keywords
Codon optimality, bias and usage in translation and mRNA decay
Sign Up to like & getrecommendations! Published in 2018 at "Nature Reviews Molecular Cell Biology"
DOI: 10.1038/nrm.2017.91
Abstract: The advent of ribosome profiling and other tools to probe mRNA translation has revealed that codon bias — the uneven use of synonymous codons in the transcriptome — serves as a secondary genetic code: a… read more here.
Keywords: translation; codon; bias; mrna decay ... See more keywords
Translation and mRNA Stability Control.
Sign Up to like & getrecommendations! Published in 2023 at "Annual review of biochemistry"
DOI: 10.1146/annurev-biochem-052621-091808
Abstract: Messenger RNA (mRNA) stability and translational efficiency are two crucial aspects of the posttranscriptional process that profoundly impact protein production in a cell. While it is widely known that ribosomes produce proteins, studies during the… read more here.
Keywords: mrna stability; codon optimality; stability; biochemistry ... See more keywords
Synonymous mutations that regulate translation speed might play a non-negligible role in liver cancer development
Sign Up to like & getrecommendations! Published in 2021 at "BMC Cancer"
DOI: 10.1186/s12885-021-08131-w
Abstract: Background Synonymous mutations do not change the protein sequences. Automatically, they have been regarded as neutral events and are ignored in the mutation-based cancer studies. However, synonymous mutations will change the codon optimality, resulting in… read more here.
Keywords: synonymous mutations; codon optimality; might play; cancer ... See more keywords