The suppression of premature termination codons and the repair of splicing mutations in CFTR
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DOI: 10.1016/j.coph.2017.09.017
Abstract: HighlightsPremature termination codons are susceptible to constitutive readthrough.Readthrough compounds may restore synthesis of a functional full‐length protein.Mutations that alter splicing induce inappropriate inclusion or skipping of an exon.Oligonucleotide‐based therapies inhibit or activate specific splicing events.… read more here.
Keywords: codons repair; termination codons; suppression premature; splicing mutations ... See more keywords