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   Articles with "coenzyme" as a keyword



Protein Scaffold‐Mediated Multi‐Enzyme Self‐Assembly and Ordered Co‐Immobilization of Flavin‐Dependent Halogenase‐Coenzyme Cycle System for Efficient Biosynthesis of 6‐Cl‐L‐Trp

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recommendations! Published in 2024 at "Biotechnology and Bioengineering"

DOI: 10.1002/bit.28871

Abstract: Flavin‐dependent halogenase (FDH) is highly prized in pharmaceutical and chemical industries for its exceptional capacity to produce halogenated aromatic compounds with precise regioselectivity. This study has devised a multi‐enzyme self‐assembly strategy to construct an effective… read more here.

Keywords: system; coenzyme; enzyme; enzyme self ... See more keywords

A Highly Selective Artificial Coenzyme: 1,1′‐Ethylene‐2,2′‐bipyridinium Dibromide for Bioelectrocatalytic Reduction of CO2 to Formate by Formate Dehydrogenase

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recommendations! Published in 2025 at "ChemCatChem"

DOI: 10.1002/cctc.202500613

Abstract: The inherent instability and suboptimal electron transfer efficiency of natural coenzymes like NADH pose fundamental challenges in enzymatic CO2 electroreduction. We address this critical limitation through an electrochemical‐enzymatic hybrid system employing 1,1′‐ethylene‐2,2′‐bipyridinium (DB∙+) as an… read more here.

Keywords: artificial coenzyme; formate dehydrogenase; coenzyme; ethylene bipyridinium ... See more keywords

Administration of coenzyme Q10 to a diabetic rat model: changes in biochemical, antioxidant, and histopathological indicators

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recommendations! Published in 2019 at "International Journal of Diabetes in Developing Countries"

DOI: 10.1007/s13410-019-00752-z

Abstract: Background Diabetes mellitus is a metabolic disorder caused by impaired glucose metabolism. Coenzyme Q10 is an endogenous vitamin with significant antioxidant properties. Aims and objective The aim of our study is to investigate the protective… read more here.

Keywords: biochemical antioxidant; group; coenzyme; coenzyme q10 ... See more keywords

Coenzyme A-regulated Pd nanocatalysts for formic acid-mediated reduction of hexavalent chromium

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recommendations! Published in 2018 at "Chemical Engineering Journal"

DOI: 10.1016/j.cej.2018.06.138

Abstract: Abstract Coenzyme A (CoA), as a cofactor of enzymes in bacteria, is involved in various reactions of intermediary metabolism owing to its thiol groups. Herein we develop a facile CoA-assisted approach for the green synthesis… read more here.

Keywords: reduction; coenzyme; formic acid; coa ... See more keywords

Coenzyme Q10 protects against statin-induced myotoxicity in zebrafish larvae (Danio rerio).

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recommendations! Published in 2017 at "Environmental toxicology and pharmacology"

DOI: 10.1016/j.etap.2017.03.021

Abstract: 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the rate-limiting enzyme of the mevalonic acid pathway and is required for cholesterol biosynthesis and the synthesis of Coenzyme Q10 (CoQ10). Statins inhibit HMGCR, thus inhibiting the downstream products of this… read more here.

Keywords: coenzyme q10; statin induced; danio rerio; coenzyme ... See more keywords

Metabolic adaptations and modulation of coenzyme Q system through nutritional interventions and CYB5R3 overexpression in transgenic mice

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.04.282

Abstract: Aging is an irreversible process associated with a variety of diseases where mitochondria play an essential role. Redox balance and the level of unsaturation in membrane phospholipids can modulate the aging process. Attenuating oxidative damage… read more here.

Keywords: system; fatty acids; coenzyme; transgenic mice ... See more keywords

Characterization and role of the 3-methylglutaconyl coenzyme A hidratase in Trypanosoma brucei.

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recommendations! Published in 2017 at "Molecular and biochemical parasitology"

DOI: 10.1016/j.molbiopara.2017.03.007

Abstract: Trypanosoma brucei, the agent of African Trypanosomiasis, is a flagellated protozoan parasite that develops in tsetse flies and in the blood of various mammals. The parasite acquires nutrients such as sugars, lipids and amino acids… read more here.

Keywords: trypanosoma brucei; methylglutaconyl coenzyme; mgcoa; coenzyme ... See more keywords

An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.

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recommendations! Published in 2019 at "Molecular cell"

DOI: 10.1016/j.molcel.2018.11.033

Abstract: The biosynthesis of coenzyme Q presents a paradigm for how cells surmount hydrophobic barriers in lipid biology. In eukaryotes, CoQ precursors-among nature's most hydrophobic molecules-must somehow be presented to a series of enzymes peripherally associated… read more here.

Keywords: coq9; biosynthesis; lipid binding; coenzyme ... See more keywords

Protein engineering of oxidoreductases utilizing nicotinamide-based coenzymes, with applications in synthetic biology

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recommendations! Published in 2017 at "Synthetic and Systems Biotechnology"

DOI: 10.1016/j.synbio.2017.09.002

Abstract: Two natural nicotinamide-based coenzymes (NAD and NADP) are indispensably required by the vast majority of oxidoreductases for catabolism and anabolism, respectively. Most NAD(P)-dependent oxidoreductases prefer one coenzyme as an electron acceptor or donor to the… read more here.

Keywords: engineering; based coenzymes; nicotinamide based; synthetic biology ... See more keywords

Reactivity Factors in Catalytic Methanogenesis and Their Tuning upon Coenzyme F430 Biosynthesis

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recommendations! Published in 2023 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.3c00469

Abstract: Methyl-coenzyme M reductase, responsible for the biological production of methane by catalyzing the reaction between coenzymes B (CoBS-H) and M (H3C-SCoM), hosts in its core an F430 cofactor with the low-valent NiI ion. The critical… read more here.

Keywords: cleavage h3c; f430; coenzyme; methanogenesis ... See more keywords

Tetraphenylethene-Based Molecular Cage with Coenzyme FAD: Conformationally Isomeric Complexation toward Photocatalysis-Assisted Photodynamic Therapy.

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recommendations! Published in 2024 at "Journal of the American Chemical Society"

DOI: 10.1021/jacs.4c09508

Abstract: Flavin adenine dinucleotide (FAD), serving as a light-absorbing coenzyme factor, can undergo conformationally isomeric complexation within different enzymes to form various enzyme-coenzyme complexes, which exhibit photocatalytic functions that play a crucial role in physiological processes.… read more here.

Keywords: molecular cage; isomeric complexation; coenzyme; fad ... See more keywords