Administration of coenzyme Q10 to a diabetic rat model: changes in biochemical, antioxidant, and histopathological indicators
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Diabetes in Developing Countries"
DOI: 10.1007/s13410-019-00752-z
Abstract: Background Diabetes mellitus is a metabolic disorder caused by impaired glucose metabolism. Coenzyme Q10 is an endogenous vitamin with significant antioxidant properties. Aims and objective The aim of our study is to investigate the protective… read more here.
Keywords: biochemical antioxidant; group; coenzyme; coenzyme q10 ... See more keywords
Coenzyme A-regulated Pd nanocatalysts for formic acid-mediated reduction of hexavalent chromium
Sign Up to like & getrecommendations! Published in 2018 at "Chemical Engineering Journal"
DOI: 10.1016/j.cej.2018.06.138
Abstract: Abstract Coenzyme A (CoA), as a cofactor of enzymes in bacteria, is involved in various reactions of intermediary metabolism owing to its thiol groups. Herein we develop a facile CoA-assisted approach for the green synthesis… read more here.
Keywords: reduction; coenzyme; formic acid; coa ... See more keywords
Coenzyme Q10 protects against statin-induced myotoxicity in zebrafish larvae (Danio rerio).
Sign Up to like & getrecommendations! Published in 2017 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2017.03.021
Abstract: 3-Hydroxy-3-methylglutaryl-CoA reductase (HMGCR) is the rate-limiting enzyme of the mevalonic acid pathway and is required for cholesterol biosynthesis and the synthesis of Coenzyme Q10 (CoQ10). Statins inhibit HMGCR, thus inhibiting the downstream products of this… read more here.
Keywords: coenzyme q10; statin induced; danio rerio; coenzyme ... See more keywords
Metabolic adaptations and modulation of coenzyme Q system through nutritional interventions and CYB5R3 overexpression in transgenic mice
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.04.282
Abstract: Aging is an irreversible process associated with a variety of diseases where mitochondria play an essential role. Redox balance and the level of unsaturation in membrane phospholipids can modulate the aging process. Attenuating oxidative damage… read more here.
Keywords: system; fatty acids; coenzyme; transgenic mice ... See more keywords
Characterization and role of the 3-methylglutaconyl coenzyme A hidratase in Trypanosoma brucei.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular and biochemical parasitology"
DOI: 10.1016/j.molbiopara.2017.03.007
Abstract: Trypanosoma brucei, the agent of African Trypanosomiasis, is a flagellated protozoan parasite that develops in tsetse flies and in the blood of various mammals. The parasite acquires nutrients such as sugars, lipids and amino acids… read more here.
Keywords: trypanosoma brucei; methylglutaconyl coenzyme; mgcoa; coenzyme ... See more keywords
An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2018.11.033
Abstract: The biosynthesis of coenzyme Q presents a paradigm for how cells surmount hydrophobic barriers in lipid biology. In eukaryotes, CoQ precursors-among nature's most hydrophobic molecules-must somehow be presented to a series of enzymes peripherally associated… read more here.
Keywords: coq9; biosynthesis; lipid binding; coenzyme ... See more keywords
Protein engineering of oxidoreductases utilizing nicotinamide-based coenzymes, with applications in synthetic biology
Sign Up to like & getrecommendations! Published in 2017 at "Synthetic and Systems Biotechnology"
DOI: 10.1016/j.synbio.2017.09.002
Abstract: Two natural nicotinamide-based coenzymes (NAD and NADP) are indispensably required by the vast majority of oxidoreductases for catabolism and anabolism, respectively. Most NAD(P)-dependent oxidoreductases prefer one coenzyme as an electron acceptor or donor to the… read more here.
Keywords: engineering; based coenzymes; nicotinamide based; synthetic biology ... See more keywords
Reactivity Factors in Catalytic Methanogenesis and Their Tuning upon Coenzyme F430 Biosynthesis
Sign Up to like & getrecommendations! Published in 2023 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.3c00469
Abstract: Methyl-coenzyme M reductase, responsible for the biological production of methane by catalyzing the reaction between coenzymes B (CoBS-H) and M (H3C-SCoM), hosts in its core an F430 cofactor with the low-valent NiI ion. The critical… read more here.
Keywords: cleavage h3c; f430; coenzyme; methanogenesis ... See more keywords
Intrastriatal administration of coenzyme Q10 enhances neuroprotection in a Parkinson’s disease rat model
Sign Up to like & getrecommendations! Published in 2020 at "Scientific Reports"
DOI: 10.1038/s41598-020-66493-w
Abstract: Parkinson’s disease is a neurodegenerative disorder, and no treatment has been yet established to prevent disease progression. Coenzyme Q10, an antioxidant, has been considered a promising neuroprotective agent; however, conventional oral administration provides limited efficacy… read more here.
Keywords: coenzyme q10; parkinson disease; coenzyme;
AgNO3-catalyzed decarboxylative cross-coupling reaction: an approach to coenzyme Q
Sign Up to like & getrecommendations! Published in 2020 at "New Journal of Chemistry"
DOI: 10.1039/d0nj01497d
Abstract: An efficient and general method for the synthesis of coenzyme Q compounds through the activation of the 1,4-benzoquinone Csp2–H bond has been developed. This C–C bond formation reaction proceeds readily in an open flask by… read more here.
Keywords: agno3 catalyzed; coupling reaction; coenzyme; reaction ... See more keywords
Coenzyme Q10: From bench to clinic in aging diseases, a translational review
Sign Up to like & getrecommendations! Published in 2018 at "Critical Reviews in Food Science and Nutrition"
DOI: 10.1080/10408398.2018.1442316
Abstract: ABSTRACT Coenzyme Q10 (CoQ10) is a ubiquitous molecule present in all eukaryotic organisms whose principal role in the cell is related to its participation in the electron transport chain in the inner mitochondrial membrane. CoQ10… read more here.
Keywords: q10 bench; coenzyme; coenzyme q10; bench clinic ... See more keywords