Inhibitors of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase (Statins) Suppress Proliferation and Motility of Human CD4+ T Lymphocytes in Culture.
Sign Up to like & getrecommendations! Published in 2021 at "Bulletin of experimental biology and medicine"
DOI: 10.1007/s10517-021-05350-w
Abstract: 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors (statins) along with their blood lipid-lowering effect exhibit anti-inflammatory and immunomodulatory activity. We studied the effects of long-term (72-h or longer) exposure of human T lymphocytes in culture to atorvastatin… read more here.
Keywords: cd4; methylglutaryl coenzyme; hydroxy methylglutaryl; lymphocytes culture ... See more keywords
The selective antifungal activity of Drosophila melanogaster metchnikowin reflects the species-dependent inhibition of succinate–coenzyme Q reductase
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DOI: 10.1038/s41598-017-08407-x
Abstract: Insect-derived antifungal peptides have a significant economic potential, particularly for the engineering of pathogen-resistant crops. However, the nonspecific antifungal activity of such peptides could result in detrimental effects against beneficial fungi, whose interactions with plants… read more here.
Keywords: selective antifungal; coenzyme reductase; succinate coenzyme; drosophila melanogaster ... See more keywords
Methyl-Coenzyme M Reductase and Its Post-translational Modifications
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DOI: 10.3389/fmicb.2020.578356
Abstract: The methyl-coenzyme M reductase (MCR) is a central enzyme in anaerobic microbial methane metabolism, which consists of methanogenesis and anaerobic oxidation of methane (AOM). MCR catalyzes the final step of methanogenesis and the first step… read more here.
Keywords: methyl coenzyme; post translational; coenzyme reductase; translational modifications ... See more keywords
The Expression Profiles of the Salvia miltiorrhiza 3-Hydroxy-3-methylglutaryl-coenzyme A Reductase 4 Gene and Its Influence on the Biosynthesis of Tanshinones
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DOI: 10.3390/molecules27144354
Abstract: Salvia miltiorrhiza is a medicinal plant that synthesises biologically-active tanshinones with numerous therapeutic properties. An important rate-limiting enzyme in the biosynthesis of their precursors is 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR). This study presents the organ-specific expression… read more here.
Keywords: biosynthesis; salvia miltiorrhiza; coenzyme reductase; methylglutaryl coenzyme ... See more keywords
The Statin Target HMG-Coenzyme a Reductase (Hmgcr) Regulates Sleep Homeostasis in Drosophila
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DOI: 10.3390/ph15010079
Abstract: Statins, HMG Coenzyme A Reductase (HMGCR) inhibitors, are a first-line therapy, used to reduce hypercholesterolemia and the risk for cardiovascular events. While sleep disturbances are recognized as a side-effect of statin treatment, the impact of… read more here.
Keywords: hmgcr regulates; reductase hmgcr; regulates sleep; hmgcr ... See more keywords
Isolation and Comprehensive in Silico Characterisation of a New 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase 4 (HMGR4) Gene Promoter from Salvia miltiorrhiza: Comparative Analyses of Plant HMGR Promoters
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DOI: 10.3390/plants11141861
Abstract: Salvia miltiorrhiza synthesises tanshinones with multidirectional therapeutic effects. These compounds have a complex biosynthetic pathway, whose first rate limiting enzyme is 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGR). In the present study, a new 1646 bp fragment of… read more here.
Keywords: salvia miltiorrhiza; coenzyme reductase; hmgr4 gene; methylglutaryl coenzyme ... See more keywords
Post-translational thioamidation of methyl-coenzyme M reductase, a key enzyme in methanogenic and methanotrophic Archaea
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DOI: 10.7554/elife.29218
Abstract: Methyl-coenzyme M reductase (MCR), found in strictly anaerobic methanogenic and methanotrophic archaea, catalyzes the reversible production and consumption of the potent greenhouse gas methane. The α subunit of MCR (McrA) contains several unusual post-translational modifications,… read more here.
Keywords: methyl coenzyme; coenzyme reductase; post translational; methanotrophic archaea ... See more keywords