Locus coeruleus neurons are most sensitive to chronic neuroinflammation-induced neurodegeneration
Sign Up to like & getrecommendations! Published in 2020 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2020.01.003
Abstract: Parkinson's disease (PD) develops over decades through spatiotemporal stages that ascend from the brainstem to the forebrain. The mechanism behind this caudo-rostral neurodegeneration remains largely undefined. In unraveling this phenomenon, we recently developed a lipopolysaccharide… read more here.
Keywords: coeruleus neurons; lps; neurodegeneration; locus coeruleus ... See more keywords
Cocaine increases quantal norepinephrine secretion through NET-dependent PKC activation in locus coeruleus neurons.
Sign Up to like & getrecommendations! Published in 2022 at "Cell reports"
DOI: 10.2139/ssrn.3979181
Abstract: The norepinephrine neurons in locus coeruleus (LC-NE neurons) are essential for sleep arousal, pain sensation, and cocaine addiction. According to previous studies, cocaine increases NE overflow (the profile of extracellular NE level in response to… read more here.
Keywords: coeruleus neurons; locus coeruleus; cocaine increases; release ... See more keywords