Intra-Domain Residue Coevolution in Transcription Factors Contributes to DNA Binding Specificity
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology Spectrum"
DOI: 10.1128/spectrum.03651-22
Abstract: While unraveling DNA-binding specificity of TFs is the key to understanding the basis and molecular mechanism of gene expression regulation, identifying the critical determinants that contribute to DNA binding specificity remains a major challenge. In… read more here.
Keywords: coevolving residues; dna; binding specificity; dna binding ... See more keywords
Coevolving residues inform protein dynamics profiles and disease susceptibility of nSNVs
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DOI: 10.1371/journal.pcbi.1006626
Abstract: The conformational dynamics of proteins is rarely used in methodologies used to predict the impact of genetic mutations due to the paucity of three-dimensional protein structures as compared to the vast number of available sequences.… read more here.
Keywords: coevolving residues; protein dynamics; conformational dynamics; inform protein ... See more keywords