Coexpression of 5‐Aminolevulinic Acid Synthase Gene Facilitates Heterologous Production of Thermostable Cytochrome P450, CYP119, in Holo Form in Escherichia coli
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800331
Abstract: Cytochrome P450 enzymes are heme‐containing monooxygenases that exhibit potential as biocatalysts for practical applications. The Escherichia coli expression system is frequently used for biocatalyst production; however, heterologous production of hemeproteins in their holo form is… read more here.
Keywords: coexpression; holo form; production; heterologous production ... See more keywords
Structural covariances of prefrontal subregions selectively associate with dopamine-related gene coexpression and schizophrenia.
Sign Up to like & getrecommendations! Published in 2023 at "Cerebral cortex"
DOI: 10.1093/cercor/bhad096
Abstract: Evidence highlights that dopamine (DA) system dysregulation and prefrontal cortex (PFC) dysfunction may underlie the pathophysiology of schizophrenia. However, the associations among DA genes, PFC morphometry, and schizophrenia have not yet been fully clarified. Based… read more here.
Keywords: coexpression schizophrenia; brain; dopamine; gene ... See more keywords
Divergent Allometric Trajectories in Gene Expression and Coexpression Produce Species Differences in Sympatrically Speciating Midas Cichlid Fish
Sign Up to like & getrecommendations! Published in 2019 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evz108
Abstract: Abstract The mechanisms of speciation without geographic isolation (i.e., sympatric speciation) remain debated. This is due in part to the fact that the genomic landscape that could promote or hinder species divergence in the presence… read more here.
Keywords: coexpression; gene expression; benthic limnetic; expression ... See more keywords
COXPRESdb v8: an animal gene coexpression database navigating from a global view to detailed investigations
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac983
Abstract: Abstract Gene coexpression is synchronization of gene expression across many cellular and environmental conditions and is widely used to infer the biological function of genes. Gene coexpression information is complex, comprising a complete graph of… read more here.
Keywords: coexpression; database; coxpresdb; gene coexpression ... See more keywords
A Global Coexpression Network Approach for Connecting Genes to Specialized Metabolic Pathways in Plants
Sign Up to like & getrecommendations! Published in 2017 at "Plant Cell"
DOI: 10.1105/tpc.17.00009
Abstract: Global gene coexpression network analysis is a powerful approach for identifying known and novel plant-specialized metabolic pathways, irrespective of the genomic location of the constitutive genes. Plants produce diverse specialized metabolites (SMs), but the genes… read more here.
Keywords: coexpression; plant; metabolic pathways; specialized metabolic ... See more keywords
Non‐small cell lung carcinomas with diffuse coexpression of TTF1 and p40: clinicopathological and genomic features of 14 rare biphenotypic tumours
Sign Up to like & getrecommendations! Published in 2022 at "Histopathology"
DOI: 10.1111/his.14801
Abstract: Thyroid transcription factor 1 (TTF1) and p40 are widely‐utilized diagnostic markers of lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC), respectively. Diffuse coexpression of TTF1 and p40 has been described in only rare case reports.… read more here.
Keywords: diffuse coexpression; lung carcinomas; ttf1 p40; coexpression ... See more keywords
Differential coexpression networks in bronchiolitis and emphysema phenotypes reveal heterogeneous mechanisms of chronic obstructive pulmonary disease
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14585
Abstract: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with multiple molecular mechanisms. To investigate and contrast the molecular processes differing between bronchiolitis and emphysema phenotypes of COPD, we downloaded the GSE69818 microarray data set… read more here.
Keywords: coexpression; chronic obstructive; analysis; obstructive pulmonary ... See more keywords
Arcuate nucleus neuropeptide coexpression and connections to gonadotrophin‐releasing hormone neurones in the female rhesus macaque
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Neuroendocrinology"
DOI: 10.1111/jne.12491
Abstract: The underlying hypothalamic neurocircuitry by which metabolism and feeding regulates reproductive function has been well‐studied in the rodent; however, recent data have demonstrated significant neuroanatomical differences in the human brain. The present study had three… read more here.
Keywords: coexpression; releasing hormone; arcuate nucleus; nucleus neuropeptide ... See more keywords
Coexpression of Matrix Metalloproteinase-7 and Tissue Inhibitor of Metalloproteinase-1 as a Prognostic Biomarker in Gastric Cancer
Sign Up to like & getrecommendations! Published in 2020 at "Disease Markers"
DOI: 10.1155/2020/8831466
Abstract: Background Degradation of the extracellular matrix (ECM), an essential step in tumour invasion and metastasis, is mainly dependent on the activities of both matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). This study aimed… read more here.
Keywords: coexpression; mmp timp; gastric cancer; metalloproteinase ... See more keywords
Identification of CD8+ T Cell-Related Genes: Correlations with Immune Phenotypes and Outcomes of Liver Cancer
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Immunology Research"
DOI: 10.1155/2021/9960905
Abstract: Purpose Treatment outcomes for advanced liver cancer are poor. Immunotherapy is a treatment strategy that has been widely used to treat other cancers. Studies have shown that CD8+ T lymphocytes are essential factors affecting the… read more here.
Keywords: coexpression; cd8; cd8 lymphocyte; cell ... See more keywords
Robust normalization and transformation techniques for constructing gene coexpression networks from RNA-seq data
Sign Up to like & getrecommendations! Published in 2022 at "Genome Biology"
DOI: 10.1186/s13059-021-02568-9
Abstract: Background Constructing gene coexpression networks is a powerful approach for analyzing high-throughput gene expression data towards module identification, gene function prediction, and disease-gene prioritization. While optimal workflows for constructing coexpression networks, including good choices for… read more here.
Keywords: coexpression networks; rna seq; coexpression; transformation ... See more keywords