Coexpression of 5‐Aminolevulinic Acid Synthase Gene Facilitates Heterologous Production of Thermostable Cytochrome P450, CYP119, in Holo Form in Escherichia coli
Sign Up to like & getrecommendations! Published in 2018 at "ChemBioChem"
DOI: 10.1002/cbic.201800331
Abstract: Cytochrome P450 enzymes are heme‐containing monooxygenases that exhibit potential as biocatalysts for practical applications. The Escherichia coli expression system is frequently used for biocatalyst production; however, heterologous production of hemeproteins in their holo form is… read more here.
Keywords: coexpression; holo form; production; heterologous production ... See more keywords
Gene Coexpression and miRNA Regulation: A Path to Early Intervention in Colorectal Cancer
Sign Up to like & getrecommendations! Published in 2024 at "Human Gene Therapy"
DOI: 10.1089/hum.2023.207
Abstract: Early diagnosis and intervention are pivotal in reducing colorectal cancer (CRC) incidence and enhancing patient outcomes. In this study, we focused on three genes, AQP8, GUCA2B, and SPIB, which exhibit high coexpression and play crucial… read more here.
Keywords: mir 182; hsa mir; gene; intervention ... See more keywords
Structural covariances of prefrontal subregions selectively associate with dopamine-related gene coexpression and schizophrenia.
Sign Up to like & getrecommendations! Published in 2023 at "Cerebral cortex"
DOI: 10.1093/cercor/bhad096
Abstract: Evidence highlights that dopamine (DA) system dysregulation and prefrontal cortex (PFC) dysfunction may underlie the pathophysiology of schizophrenia. However, the associations among DA genes, PFC morphometry, and schizophrenia have not yet been fully clarified. Based… read more here.
Keywords: coexpression schizophrenia; brain; dopamine; gene ... See more keywords
Divergent Allometric Trajectories in Gene Expression and Coexpression Produce Species Differences in Sympatrically Speciating Midas Cichlid Fish
Sign Up to like & getrecommendations! Published in 2019 at "Genome Biology and Evolution"
DOI: 10.1093/gbe/evz108
Abstract: Abstract The mechanisms of speciation without geographic isolation (i.e., sympatric speciation) remain debated. This is due in part to the fact that the genomic landscape that could promote or hinder species divergence in the presence… read more here.
Keywords: coexpression; gene expression; benthic limnetic; expression ... See more keywords
Diverse effects of coexpression of human SOD1 variants on motor neuron disease
Sign Up to like & getrecommendations! Published in 2025 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddaf088
Abstract: Abstract Mutations in superoxide dismutase-1 (SOD1) are a common cause of amyotrophic lateral sclerosis (ALS). Inheritance is as a rule dominant, but in carriers of the most common mutation, D90A, disease can develop in both… read more here.
Keywords: disease; motor neuron; neuron disease; sod1 ... See more keywords
COXPRESdb v8: an animal gene coexpression database navigating from a global view to detailed investigations
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac983
Abstract: Abstract Gene coexpression is synchronization of gene expression across many cellular and environmental conditions and is widely used to infer the biological function of genes. Gene coexpression information is complex, comprising a complete graph of… read more here.
Keywords: coexpression; database; coxpresdb; gene coexpression ... See more keywords
EPCO-33. OMICON: A CLOUD PLATFORM FOR FAIR RESEARCH ON GENE COEXPRESSION NETWORKS IN NORMAL HUMAN BRAIN AND BRAIN TUMORS
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0032
Abstract: Genome-wide coexpression analysis of bulk human brain samples is a powerful approach for identifying highly reproducible transcriptional signatures of cell types and cell states, since it can survey huge numbers of individuals, cells, and transcripts.… read more here.
Keywords: gene coexpression; human brain; coexpression networks; gene ... See more keywords
Bayesian inference of sample-specific coexpression networks
Sign Up to like & getrecommendations! Published in 2024 at "Genome Research"
DOI: 10.1101/gr.279117.124
Abstract: Gene regulatory networks (GRNs) are effective tools for inferring complex interactions between molecules that regulate biological processes and hence can provide insights into drivers of biological systems. Inferring coexpression networks is a critical element of… read more here.
Keywords: specific coexpression; sample specific; gene; coexpression networks ... See more keywords
A Global Coexpression Network Approach for Connecting Genes to Specialized Metabolic Pathways in Plants
Sign Up to like & getrecommendations! Published in 2017 at "Plant Cell"
DOI: 10.1105/tpc.17.00009
Abstract: Global gene coexpression network analysis is a powerful approach for identifying known and novel plant-specialized metabolic pathways, irrespective of the genomic location of the constitutive genes. Plants produce diverse specialized metabolites (SMs), but the genes… read more here.
Keywords: coexpression; plant; metabolic pathways; specialized metabolic ... See more keywords
Non‐small cell lung carcinoma with focal coexpression of thyroid transcription factor‐1 and Δ Np63/p40: A case report
Sign Up to like & getrecommendations! Published in 2024 at "Thoracic Cancer"
DOI: 10.1111/1759-7714.15271
Abstract: Most lung carcinomas are subtyped by their morphologies; however, immunohistochemistry is usually performed when it is difficult to determine. The most reliable antibodies for distinguishing lung adenocarcinoma from squamous cell carcinoma are thyroid transcription factor‐1… read more here.
Keywords: lung; transcription factor; carcinoma; cell ... See more keywords
Non‐small cell lung carcinomas with diffuse coexpression of TTF1 and p40: clinicopathological and genomic features of 14 rare biphenotypic tumours
Sign Up to like & getrecommendations! Published in 2022 at "Histopathology"
DOI: 10.1111/his.14801
Abstract: Thyroid transcription factor 1 (TTF1) and p40 are widely‐utilized diagnostic markers of lung adenocarcinoma (LUAD) and squamous cell carcinoma (LUSC), respectively. Diffuse coexpression of TTF1 and p40 has been described in only rare case reports.… read more here.
Keywords: diffuse coexpression; lung carcinomas; ttf1 p40; coexpression ... See more keywords