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   Articles with "cofactor" as a keyword



Heme Cofactor‐Resembling Fe–N Single Site Embedded Graphene as Nanozymes to Selectively Detect H2O2 with High Sensitivity

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recommendations! Published in 2019 at "Advanced Functional Materials"

DOI: 10.1002/adfm.201905410

Abstract: Over the past decade, the catalytic activity of nanozymes has been greatly enhanced, but their selectivity is still low and considered a critical issue to overcome. Herein, Fe–N4 single site embedded graphene (Fe–N‐rGO), which resembles… read more here.

Keywords: cofactor; single site; embedded graphene; site embedded ... See more keywords

Construction of dual cofactor‐driven biocatalytic system for effective production of chiral amino acids

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recommendations! Published in 2025 at "AIChE Journal"

DOI: 10.1002/aic.18894

Abstract: Asymmetric reductive amination is essential for producing chiral amino acids, yet optimizing intracellular cofactor utilization for this process remains challenging. Herein, we developed a dual cofactor‐driven biocatalytic system (DuCoCat) that utilizes both intracellular NAD(H) and… read more here.

Keywords: system; cofactor; dual cofactor; driven biocatalytic ... See more keywords

Enhancing cofactor recycling in the bioconversion of racemic alcohols to chiral amines with alcohol dehydrogenase and amine dehydrogenase by coupling cells and cell‐free system

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recommendations! Published in 2019 at "Biotechnology and Bioengineering"

DOI: 10.1002/bit.26896

Abstract: Alcohol dehydrogenase (ADH) and amine dehydrogenase (AmDH)‐catalyzed one‐pot cascade conversion of an alcohol to an amine provides a simple preparation of chiral amines. To enhance the cofactor recycling in this reaction, we report a new… read more here.

Keywords: dehydrogenase; racemic alcohols; conversion; alcohol dehydrogenase ... See more keywords

Three in One: Temperature, Solvent and Catalytic Stability by Engineering the Cofactor‐Binding Element of Amine Transaminase

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recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201700236

Abstract: Amine transaminase (ATA) catalyse enantioselectively the direct amination of ketones, but insufficient stability during catalysis limits their industrial applicability. Recently, we revealed that ATAs suffer from substrate‐induced inactivation mechanism involving dissociation of the enzyme–cofactor intermediate.… read more here.

Keywords: engineering cofactor; amine transaminase; binding element; stability ... See more keywords
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A Comparative Analysis of the CO‐Reducing Activities of MoFe Proteins Containing Mo‐ and V‐Nitrogenase Cofactors

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recommendations! Published in 2018 at "ChemBioChem"

DOI: 10.1002/cbic.201800035

Abstract: The Mo and V nitrogenases are structurally homologous yet catalytically distinct in their abilities to reduce CO to hydrocarbons. Here we report a comparative analysis of the CO‐reducing activities of the Mo‐ and V‐nitrogenase cofactors… read more here.

Keywords: comparative analysis; analysis reducing; nitrogenase cofactors; reducing activities ... See more keywords

Incorporation of an Asymmetric Mo−Fe−S Cluster as an Artificial Cofactor into Nitrogenase

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recommendations! Published in 2022 at "ChemBioChem"

DOI: 10.1002/cbic.202200384

Abstract: Nitrogenase employs a sophisticated electron transfer system and a Mo−Fe−S−C cofactor, designated the M‐cluster [(cit)MoFe7S9C]), to reduce atmospheric N2 to bioaccessible NH3. Previously, we have shown that the cofactor‐free form of nitrogenase can be repurposed… read more here.

Keywords: artificial cofactor; nitrogenase; cofactor; cluster ... See more keywords

Activity‐Enhancing Mutations in an LmrR‐Based Artificial Metalloenzyme Destabilize the Protein Scaffold and Alter its Conformational Plasticity

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recommendations! Published in 2025 at "Chembiochem"

DOI: 10.1002/cbic.202500259

Abstract: Artificial metalloenzymes (ArM) hold great potential for the sustainable catalysis of complex new‐to‐nature reactions. To efficiently improve the catalytic efficacy of ArMs, a rational approach is desirable, requiring detailed molecular insight into their conformational landscape.… read more here.

Keywords: activity enhancing; cofactor; plasticity; protein scaffold ... See more keywords

Orthogonal Valorization of 5‐Hydroxymethylfurfural Using Self‐Sufficient Heterogeneous Biocatalysts Composed of Two Co‐Immobilized Dehydrogenases

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recommendations! Published in 2025 at "ChemCatChem"

DOI: 10.1002/cctc.202500734

Abstract: 5‐Hydroxymethyl furfural (HMF) is a key molecule in biorefineries, but its conversion into valuable products faces technological challenges. Biocatalysis offers a sustainable solution, yet high cofactor costs and poor enzyme recyclability hinder industrial implementation. In… read more here.

Keywords: heterogeneous biocatalysts; cofactor; sufficient heterogeneous; valorization ... See more keywords

The ins and outs of the flavin mononucleotide cofactor of respiratory complex I

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recommendations! Published in 2022 at "IUBMB Life"

DOI: 10.1002/iub.2600

Abstract: The flavin mononucleotide (FMN) cofactor of respiratory complex I occupies a key position in the electron transport chain. Here, the electrons coming from NADH start the sequence of oxidoreduction reactions, which drives the generation of… read more here.

Keywords: respiratory complex; cofactor respiratory; cofactor; ins outs ... See more keywords
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B Vitamins: Small molecules, big effects

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recommendations! Published in 2019 at "Journal of Inherited Metabolic Disease"

DOI: 10.1002/jimd.12127

Abstract: The B vitamins comprise a group of eight water soluble vitamins (thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5), pyridoxine (B6), biotin (B7), folate (B9) and cobalamin (B12)) with a myriad of cofactor roles… read more here.

Keywords: metabolism; deficiency; disease; cofactor ... See more keywords

Extensive Molecular Dynamics Simulations Disclosed the Stability of mPGES‐1 Enzyme and the Structural Role of Glutathione (GSH) Cofactor

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recommendations! Published in 2022 at "Molecular Informatics"

DOI: 10.1002/minf.202200140

Abstract: A deep in silico investigation of various microsomal prostaglandin E2 synthase‐1 (mPGES‐1) protein systems is here reported using molecular dynamics (MD) simulations. Firstly, eight different proteins models (Models A−H) were built, starting from the active… read more here.

Keywords: dynamics simulations; gsh; role; molecular dynamics ... See more keywords