c‐Abl tyrosine kinase regulates neutrophil crawling behavior under fluid shear stress via Rac/PAK/LIMK/cofilin signaling axis
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26453
Abstract: The excessive recruitment and improper activation of polymorphonuclear neutrophils (PMNs) often induces serious injury of host tissues, leading to inflammatory disorders. Therefore, to understand the molecular mechanism on neutrophil recruitment possesses essential pathological and physiological… read more here.
Keywords: abl kinase; kinase; shear stress; cofilin signaling ... See more keywords
Aberrant Rac1-cofilin signaling mediates defects in dendritic spines, synaptic function, and sensory perception in fragile X syndrome
Sign Up to like & getrecommendations! Published in 2017 at "Science Signaling"
DOI: 10.1126/scisignal.aan0852
Abstract: Inhibiting Rac1-PAK-LIMK signaling may restore synaptic function and sensory processing in patients with fragile X syndrome. Rac1-PAK signaling a target for FXS therapy? The inherited intellectual disability and autism-associated disorder fragile X syndrome (FXS) is… read more here.
Keywords: fxs; fragile syndrome; cofilin signaling; cofilin ... See more keywords