Processing and secretion of non-cognate bacteriocins by EnkT, an ABC transporter from a multiple-bacteriocin producer, Enterococcus faecium NKR-5-3.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of bioscience and bioengineering"
DOI: 10.1016/j.jbiosc.2020.07.017
Abstract: EnkT is an ATP-binding cassette (ABC) transporter produced by Enterococcus faecium NKR-5-3, which is responsible for the secretion of multiple bacteriocins; enterocins NKR-5-3A, C, D, and Z (Ent53A, C, D, and Z). EnkT has been… read more here.
Keywords: bacteriocin; cognate; abc transporter; non cognate ... See more keywords
Inter-domain Flexibility of Human Ser/Arg-Rich Splicing Factor 1 Allows Variable Spacer Length in Cognate RNA's Bipartite Motifs.
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DOI: 10.1021/acs.biochem.2c00565
Abstract: Ser/Arg-rich splicing factor 1 (SRSF1 or ASF/SF2) is the prototypical member of SR proteins. SRSF1 binds to exonic splicing enhancers, which prompts inclusion of corresponding exons in the mature mRNA. The RNA-binding domain of SRSF1… read more here.
Keywords: rna binding; bipartite motifs; rna; cognate ... See more keywords
Rapid video-based deep learning of cognate versus non-cognate T cell-dendritic cell interactions
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DOI: 10.1038/s41598-021-04286-5
Abstract: Identification of cognate interactions between antigen-specific T cells and dendritic cells (DCs) is essential to understanding immunity and tolerance, and for developing therapies for cancer and autoimmune diseases. Conventional techniques for selecting antigen-specific T cells… read more here.
Keywords: deep learning; non cognate; antigen specific; cell ... See more keywords
V-CARMA: A tool for the detection and modification of antigen-specific T cells
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2116277119
Abstract: Significance Immunotherapy is a promising approach to treat cancers, infectious diseases, and autoimmunity by harnessing the power of immune cells, especially T cells. To improve the precision and efficacy of immunotherapy, the ability to genetically… read more here.
Keywords: mhc; specific cells; cognate; target cells ... See more keywords
Molecular dynamics simulations of cognate and non-cognate AspRS-tRNAAsp complexes
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1711188
Abstract: Abstract Aspartyl tRNA synthetase (AspRS), one of the 20 aminoacyl-tRNA synthetases, plays an important role in protein synthesis by catalyzing the aminoacylation reaction and synthesises Aspartyl-tRNA (tRNAAsp). A typical three-dimensional structure of AspRS comprises three… read more here.
Keywords: cognate non; cognate; non cognate; recognition ... See more keywords
Cognate sensor kinase‐independent activation of Mycobacterium tuberculosis response regulator DevR (DosR) by acetyl phosphate: implications in anti‐mycobacterial drug design
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DOI: 10.1111/mmi.14196
Abstract: The DevRS/DosT two‐component system is essential for mycobacterial survival under hypoxia, a prevailing stress within granulomas. DevR (also known as DosR) is activated by an inducing stimulus, such as hypoxia, through conventional phosphorylation by its… read more here.
Keywords: acetyl phosphate; cognate; devr; sensor ... See more keywords
The phosphorelay BarA/SirA activates the non-cognate regulator RcsB in Salmonella enterica
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DOI: 10.1371/journal.pgen.1008722
Abstract: To survive an environmental stress, organisms must detect the stress and mount an appropriate response. One way that bacteria do so is by phosphorelay systems that respond to a stress by activating a regulator that… read more here.
Keywords: cognate; regulator rcsb; sira; regulator ... See more keywords
ThrRS-Mediated Translation Regulation of the RNA Polymerase III Subunit RPC10 Occurs through an Element with Similarity to Cognate tRNA ASL and Affects tRNA Levels
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DOI: 10.3390/genes14020462
Abstract: Aminoacyl tRNA synthetases (aaRSs) are a well-studied family of enzymes with a canonical role in charging tRNAs with a specific amino acid. These proteins appear to also have non-canonical roles, including post-transcriptional regulation of mRNA… read more here.
Keywords: rna polymerase; cognate; subunit; trna ... See more keywords
Cognate DNA Recognition by Engrailed Homeodomain Involves A Conformational Change Controlled via An Electrostatic-Spring-Loaded Latch
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DOI: 10.3390/ijms23052412
Abstract: Transcription factors must scan genomic DNA, recognize the cognate sequence of their control element(s), and bind tightly to them. The DNA recognition process is primarily carried out by their DNA binding domains (DBD), which interact… read more here.
Keywords: cognate dna; dna; cognate; dna recognition ... See more keywords