Deprescribing Education vs Usual Care for Patients With Cognitive Impairment and Primary Care Clinicians
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Internal Medicine"
DOI: 10.1001/jamainternmed.2022.0502
Abstract: Key Points Question Can increasing awareness about deprescribing prior to primary care visits reduce the use of potentially inappropriate long-term medications for individuals with cognitive impairment? Findings In this pragmatic cluster randomized clinical trial of… read more here.
Keywords: cognitive impairment; care clinicians; care; primary care ... See more keywords
Alcohol Consumption and Risk of Dementia and Cognitive Decline Among Older Adults With or Without Mild Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.10319
Abstract: Key Points Question Is alcohol consumption associated with the risk of dementia and cognitive decline in older adults with or without mild cognitive impairment? Findings In this cohort study of 3021 participants aged 72 years… read more here.
Keywords: risk dementia; alcohol consumption; cognitive impairment; without mild ... See more keywords
Association of β-Amyloid Burden With Sleep Dysfunction and Cognitive Impairment in Elderly Individuals With Cognitive Disorders
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.13383
Abstract: Key Points Question Is β-amyloid deposition in the brain associated with sleep dysfunction and cognition in elderly individuals with cognitive disorders? Findings In this survey study of 52 participants aged 65 years and older, β-amyloid… read more here.
Keywords: elderly individuals; cognitive impairment; cognitive disorders; individuals cognitive ... See more keywords
Comparative Effectiveness of Behavioral Interventions on Quality of Life for Older Adults With Mild Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2019 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2019.3016
Abstract: This cluster randomized, multicomponent comparative effectiveness trial compares the incremental effects of combinations of 5 behavioral interventions on outcomes of highest importance to patients with mild cognitive impairment. read more here.
Keywords: effectiveness behavioral; cognitive impairment; behavioral interventions; comparative effectiveness ... See more keywords
Association of Modifiable Lifestyle Factors With Cortical Amyloid Burden and Cerebral Glucose Metabolism in Older Adults With Mild Cognitive Impairment
Sign Up to like & getrecommendations! Published in 2020 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2020.5719
Abstract: Key Points Question Are modifiable lifestyle factors associated with cortical amyloid burden or cerebral glucose metabolism in older adults with mild cognitive impairment? Findings This cohort study included 118 older adults with mild cognitive impairment… read more here.
Keywords: adults mild; cognitive impairment; impairment; cerebral glucose ... See more keywords
Risk of Mild Cognitive Impairment or Probable Dementia in New Users of Angiotensin II Receptor Blockers and Angiotensin-Converting Enzyme Inhibitors
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Network Open"
DOI: 10.1001/jamanetworkopen.2022.20680
Abstract: Key Points Question Is initiation of angiotensin II receptor blockers (ARBs), compared with angiotensin-converting enzyme inhibitors (ACEIs), associated with a reduced risk of cognitive impairment, after controlling for potential pretreatment confounders? Findings This active-comparator, new-user… read more here.
Keywords: new users; angiotensin receptor; cognitive impairment; receptor blockers ... See more keywords
Association of Initial β-Amyloid Levels With Subsequent Flortaucipir Positron Emission Tomography Changes in Persons Without Cognitive Impairment.
Sign Up to like & getrecommendations! Published in 2020 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2020.3921
Abstract: Importance Tau accumulation in Alzheimer disease (AD) is closely associated with cognitive impairment. Quantitating tau accumulation by positron emission tomography (PET) will be a useful outcome measure for future clinical trials in the AD spectrum.… read more here.
Keywords: accumulation; pet; tau accumulation; suvr units ... See more keywords
Association of Elevated Amyloid and Tau Positron Emission Tomography Signal With Near-Term Development of Alzheimer Disease Symptoms in Older Adults Without Cognitive Impairment.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.2379
Abstract: Importance National Institute on Aging-Alzheimer's Association (NIA-AA) workgroups have proposed biological research criteria intended to identify individuals with preclinical Alzheimer disease (AD). Objective To assess the clinical value of these biological criteria to identify older… read more here.
Keywords: near term; tau; without cognitive; alzheimer disease ... See more keywords
Racial and Ethnic Differences in Amyloid PET Positivity in Individuals With Mild Cognitive Impairment or Dementia
Sign Up to like & getrecommendations! Published in 2022 at "JAMA Neurology"
DOI: 10.1001/jamaneurol.2022.3157
Abstract: Key Points Question Do amyloid positron emission tomography (PET) positivity rates differ across racial and ethnic groups with mild cognitive impairment (MCI) or dementia? Findings In this cohort study of 17 107 Medicare beneficiaries with MCI… read more here.
Keywords: mild cognitive; pet positivity; racial ethnic; cognitive impairment ... See more keywords
Frequency and Underlying Pathology of Pure Vascular Cognitive Impairment.
Sign Up to like & getrecommendations! Published in 2022 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2022.3472
Abstract: Importance It is not clear how common pure vascular cognitive impairment (VCI) is in the absence of Alzheimer disease (AD) and/or other neurodegenerative pathologies. Objective To identify participants without AD and other neurodegenerative pathologies and… read more here.
Keywords: pure vascular; pathology; cognitive impairment; disease ... See more keywords
Isosorbide Mononitrate and Cilostazol Treatment in Patients With Symptomatic Cerebral Small Vessel Disease: The Lacunar Intervention Trial-2 (LACI-2) Randomized Clinical Trial.
Sign Up to like & getrecommendations! Published in 2023 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2023.1526
Abstract: Importance Cerebral small vessel disease (cSVD) is a common cause of stroke (lacunar stroke), is the most common cause of vascular cognitive impairment, and impairs mobility and mood but has no specific treatment. Objective To… read more here.
Keywords: cilostazol; trial; cognitive impairment; isosorbide mononitrate ... See more keywords