Components of the choline oxidation pathway modify the association between the apolipoprotein ε4 gene variant and cognitive decline in patients with dementia
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DOI: 10.1016/j.brainres.2019.146519
Abstract: BACKGROUND Metabolites involved in one-carbon metabolism (OCM) may predict cognitive prognosis in dementia. The link between OCM, apolipoprotein E (APOE), and DNA methylation creates a biologically plausible mechanism of interaction. AIM To assess OCM metabolites… read more here.
Keywords: cognitive prognosis; components choline; decline; patients dementia ... See more keywords
Mild cognitive impairment reverters have a favorable cognitive prognosis and cortical integrity in Parkinson's disease
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DOI: 10.1016/j.neurobiolaging.2019.02.023
Abstract: This study aimed to investigate whether reversion to cognitively normal status (CogN) is related to a favorable cognitive prognosis in Parkinson's disease with mild cognitive impairment (PD-MCI). We recruited 217 patients with PD-MCI who underwent… read more here.
Keywords: mci reverters; cognitive prognosis; parkinson disease; favorable cognitive ... See more keywords
Depressive symptoms are associated with worse cognitive prognosis in patients with newly diagnosed idiopathic Parkinson disease
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DOI: 10.1111/psyg.12601
Abstract: Although depression is very common in patients with Parkinson disease (PD), only a few studies have investigated the longitudinal effects of initial depression on cognitive decline in these patients. The purpose of this study was… read more here.
Keywords: depressive symptoms; cognitive prognosis; worse cognitive; symptoms associated ... See more keywords