Connectome Signatures of Hyperexcitation in Cognitively Intact Middle-Aged Female APOE-ε4 Carriers.
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DOI: 10.1093/cercor/bhaa190
Abstract: Synaptic dysfunction is hypothesized to be one of the earliest brain changes in Alzheimer's disease, leading to "hyperexcitability" in neuronal circuits. In this study, we evaluated a novel hyperexcitation indicator (HI) for each brain region… read more here.
Keywords: apoe; cognitively intact; intact middle; apoe carriers ... See more keywords
Role of apolipoprotein E epsilon 4 (APOE*ε4) as an independent risk factor for incident depression over a 12-year period in cognitively intact adults across the lifespan
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DOI: 10.1192/bjo.2020.29
Abstract: Background The apolipoprotein E ε4 allele (APOE*ε4) is indicated as a risk for Alzheimer's disease and other age-related diseases. The risk attributable to APOE*ε4 for depression is less clear and may be because of confounding… read more here.
Keywords: depression; risk; cognitively intact; year period ... See more keywords
Ultrabrief Screens for Detecting Delirium in Postoperative Cognitively Intact Older Adults.
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DOI: 10.12788/jhm.3410
Abstract: The authors' sought to develop an ultrabrief screen for postoperative delirium in cognitively intact patients older than 70 years undergoing major elective surgery. All possible combinations of one-, two- and three-item screens and their sensitivities,… read more here.
Keywords: detecting delirium; cognitively intact; screens detecting; delirium postoperative ... See more keywords