Challenges in Communicating and Understanding Predictive Biomarker Imaging for Alzheimer Disease.
Sign Up to like & getrecommendations! Published in 2018 at "JAMA neurology"
DOI: 10.1001/jamaneurol.2017.2558
Abstract: Accumulating evidence indicates that the pathophysiological process underlying Alzheimer disease—including protein aggregation, synaptic dysfunction, and neuronal loss—begins years if not decades prior to the onset of clinical symptoms and functional limitation. This long prodromal period… read more here.
Keywords: neurology; alzheimer disease; study; disease ... See more keywords
Neuroimaging biomarkers and impaired olfaction in cognitively normal individuals
Sign Up to like & getrecommendations! Published in 2017 at "Annals of Neurology"
DOI: 10.1002/ana.24960
Abstract: There is a need for inexpensive noninvasive tests to identify older healthy persons at risk for Alzheimer disease (AD) for enrollment in AD prevention trials. Our objective was to examine whether abnormalities in neuroimaging measures… read more here.
Keywords: impaired olfaction; olfaction cognitively; neuroimaging biomarkers; biomarkers impaired ... See more keywords
Subcortical amyloid relates to cortical morphology in cognitively normal individuals
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Nuclear Medicine and Molecular Imaging"
DOI: 10.1007/s00259-019-04446-w
Abstract: PurposeAmyloid (Aβ) brain deposition can occur in cognitively normal individuals and is associated with cortical volume abnormalities. Aβ-related volume changes are inconsistent across studies. Since volume is composed of surface area and thickness, the relative… read more here.
Keywords: normal individuals; surface area; volume; cognitively normal ... See more keywords
Early neuroinflammation is associated with lower amyloid and tau levels in cognitively normal older adults
Sign Up to like & getrecommendations! Published in 2021 at "Brain, Behavior, and Immunity"
DOI: 10.1016/j.bbi.2021.01.010
Abstract: CNS inflammation is a key factor in Alzheimer's Disease (AD), but its relation to pathological Aβ, tau, and APOE4 is poorly understood, particularly prior to the onset of cognitive symptoms. To better characterize early relationships… read more here.
Keywords: tau; neuroinflammation; cognitively normal; pathology ... See more keywords
Medial temporal lobe white matter pathway variability is associated with individual differences in episodic memory in cognitively normal older adults
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2019.11.011
Abstract: Significant evidence demonstrates that aging is associated with variability in cognitive performance, even among individuals who are cognitively normal. In this study, we examined measures from magnetic resonance imaging and cerebrospinal fluid (CSF) to investigate… read more here.
Keywords: individual differences; matter; cognitively normal; associated individual ... See more keywords
Association of enlarged perivascular spaces with Aβ and tau deposition in cognitively normal older population
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.12.014
Abstract: The relationship between magnetic resonance imaging (MRI)-visible enlarged perivascular spaces (EPVS) and Aβ and tau deposition is poorly investigated in cognitively normal older population. In our study, a total of 106 cognitively normal older subjects… read more here.
Keywords: high degree; cognitively normal; epvs; degree ... See more keywords
Structural volume and cortical thickness differences between males and females in cognitively normal, cognitively impaired and Alzheimer’s dementia population
Sign Up to like & getrecommendations! Published in 2021 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2021.05.018
Abstract: We investigated differences due to sex in brain structural volume and cortical thickness in older cognitively normal (N=742), cognitively impaired (MCI; N=540) and Alzheimer's Dementia (AD; N=402) individuals from the ADNI and AIBL datasets (861… read more here.
Keywords: volume cortical; structural volume; cortical thickness; cognitively normal ... See more keywords
Cognitive and physical declines and falls in older people with and without mild cognitive impairment: a 7-year longitudinal study.
Sign Up to like & getrecommendations! Published in 2023 at "International psychogeriatrics"
DOI: 10.1017/s1041610223000315
Abstract: OBJECTIVES We examined longitudinal changes in cognitive and physical function and associations between change in function and falls in people with and without mild cognitive impairment (MCI). DESIGN Prospective cohort study with assessments every 2… read more here.
Keywords: function; cognitive physical; physical function; without mild ... See more keywords
Visual paired associate learning deficits associated with elevated beta-amyloid in cognitively normal older adults.
Sign Up to like & getrecommendations! Published in 2019 at "Neuropsychology"
DOI: 10.1037/neu0000561
Abstract: OBJECTIVE Previous studies have shown that paired associate learning (PAL), a type of episodic memory, is impaired in early Alzheimer's disease (AD). Such tasks require that a set of associations (e.g., pattern-location) be learned over… read more here.
Keywords: paired associate; time; cognitively normal; associate learning ... See more keywords
Impact of Amyloid Burden on Regional Functional Synchronization in the Cognitively Normal Older Adults
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-15001-8
Abstract: Previous studies have shown aberrant functional connectivity in preclinical Alzheimer’s disease (AD). However, the effects of beta-amyloid (Aβ) retention on regional functional synchronization in cognitively normal older adults still remain unclear. The aim of this… read more here.
Keywords: functional synchronization; cognitively normal; regional functional; older adults ... See more keywords
Peripheral Insulin Resistance in Cognitively Normal Older Adults Relates to Poorer Performance on a Test for Speed of Processing
Sign Up to like & getrecommendations! Published in 2020 at "Current Developments in Nutrition"
DOI: 10.1093/cdn/nzaa040_076
Abstract: Peripheral insulin resistance (IR) and impaired glucose metabolism increases the risk for cognitive decline. However, data looking at peripheral IR's relationship with cognition in cognitively normal adults is limited. This study aimed to assess the… read more here.
Keywords: test; cognitively normal; sop; insulin resistance ... See more keywords