Intrusion errors moderate the relationship between blood glucose and regional cerebral blood flow in cognitively unimpaired older adults.
Sign Up to like & getrecommendations! Published in 2021 at "Brain imaging and behavior"
DOI: 10.1007/s11682-021-00495-8
Abstract: Regional cerebral blood flow (CBF) has a complex relationship with cognitive functioning such that cognitively unimpaired individuals at risk for Alzheimer's disease (AD) may show regional hyperperfusion, while those with cognitive impairment typically show hypoperfusion.… read more here.
Keywords: intrusion errors; cbf; cognitively unimpaired; blood ... See more keywords
Biomarker profiling beyond amyloid and tau: cerebrospinal fluid markers, hippocampal atrophy, and memory change in cognitively unimpaired older adults
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.04.002
Abstract: Brain changes occurring in aging can be indexed by biomarkers. We used cluster analysis to identify subgroups of cognitively unimpaired individuals (n = 99, 64-93 years) with different profiles of the cerebrospinal fluid biomarkers beta amyloid 1-42… read more here.
Keywords: amyloid tau; cognitively unimpaired; older adults; beyond amyloid ... See more keywords
The relation between APOE genotype and cerebral microbleeds in cognitively unimpaired middle- and old-aged individuals
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.06.015
Abstract: Positive associations between cerebral microbleeds (CMBs) and APOE-ε4 (apolipoprotein E) genotype have been reported in Alzheimer's disease, but show conflicting results. We investigated the effect of APOE genotype on CMBs in a cohort of cognitively… read more here.
Keywords: apoe genotype; middle old; old aged; cognitively unimpaired ... See more keywords
Design and validation of the 1-week memory battery for assessing episodic memory and accelerated long-term forgetting in cognitively unimpaired subjects.
Sign Up to like & getrecommendations! Published in 2023 at "Neuropsychology"
DOI: 10.1037/neu0000879.supp
Abstract: OBJECTIVE Subtle decline in memory is thought to arise in the preclinical phase of Alzheimer's disease (AD). However, detecting these initial cognitive difficulties cross-sectionally has been challenging, and the exact nature of the decline is… read more here.
Keywords: cognitively unimpaired; long term; term forgetting; week ... See more keywords
0421 Decreased Actigraphic Daytime Activity is Associated with Lower Memory Performance in Cognitively-Unimpaired Individuals with Autosomal Dominant Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2020 at "Sleep"
DOI: 10.1093/sleep/zsaa056.418
Abstract: Alzheimer’s disease (AD) impacts brain regions that control circadian regulation systems such as wakefulness and daytime physical activity. Recent evidence shows that AD pathology is damaging for wake-promoting neurons. Whether early changes in wakefulness and… read more here.
Keywords: cognitively unimpaired; activity; daytime activity; memory performance ... See more keywords
Family members' perspectives on learning cognitively unimpaired older adults' amyloid-β PET scan results.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of the American Geriatrics Society"
DOI: 10.1111/jgs.17362
Abstract: BACKGROUND/OBJECTIVES Disclosure of Alzheimer's disease (AD) risk information to cognitively unimpaired older adults may become more common if preclinical AD is shown to be identifiable and amenable to treatment. Little, however, is known about how… read more here.
Keywords: dementia risk; risk; information; family ... See more keywords
Predicting Amyloid Positivity in Cognitively Unimpaired Older Adults: A Machine Learning Approach Using the A4 Data.
Sign Up to like & getrecommendations! Published in 2022 at "Neurology"
DOI: 10.1212/wnl.0000000000200553
Abstract: OBJECTIVE To develop and test the performance of Positive Aβ Risk Score (PARS) for prediction of Aβ positivity in cognitively unimpaired individuals for use in clinical research. BACKGROUND Detecting β-amyloid (Aβ) positivity is essential for… read more here.
Keywords: pars model; risk; positivity cognitively; positivity ... See more keywords
Resting state electroencephalographic rhythms are affected by immediately preceding memory demands in cognitively unimpaired elderly and patients with mild cognitive impairment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.907130
Abstract: Experiments on event-related electroencephalographic oscillations in aged people typically include blocks of cognitive tasks with a few minutes of interval between them. The present exploratory study tested the effect of being engaged on cognitive tasks… read more here.
Keywords: cognitively unimpaired; mild cognitive; memory tasks; resting state ... See more keywords
Sleepiness in Cognitively Unimpaired Older Adults Is Associated With CSF Biomarkers of Inflammation and Axonal Integrity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2022.930315
Abstract: Introduction Sleepiness has been associated with cognitive decline and dementia in the elderly. Older adults with excessive daytime sleepiness appear to be more vulnerable to longitudinal amyloid PET accumulation before the onset of the dementia.… read more here.
Keywords: axonal integrity; sleepiness; cognitively unimpaired; older adults ... See more keywords
Classification and prediction of cognitive trajectories of cognitively unimpaired individuals
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Aging Neuroscience"
DOI: 10.3389/fnagi.2023.1122927
Abstract: Objectives Efforts to prevent Alzheimer’s disease (AD) would benefit from identifying cognitively unimpaired (CU) individuals who are liable to progress to cognitive impairment. Therefore, we aimed to develop a model to predict cognitive decline among… read more here.
Keywords: cognitively unimpaired; smc; model; cognitive trajectories ... See more keywords
Association between Motor Signs and Cognitive Performance in Cognitively Unimpaired Older Adults: A Cross-Sectional Study Using the NACC Database
Sign Up to like & getrecommendations! Published in 2022 at "Brain Sciences"
DOI: 10.3390/brainsci12101365
Abstract: Aiming to examine whether specific motor signs are associated with worse performance in specific cognitive domains among cognitively unimpaired (CU) individuals, we performed a cross-sectional analysis of data from the baseline evaluations of older, CU… read more here.
Keywords: cognitively unimpaired; cross sectional; motor signs; motor ... See more keywords