Releasing the cohesin ring: A rigid scaffold model for opening the DNA exit gate by Pds5 and Wapl
Sign Up to like & getrecommendations! Published in 2017 at "BioEssays"
DOI: 10.1002/bies.201600207
Abstract: The ring-shaped ATPase machine, cohesin, regulates sister chromatid cohesion, transcription, and DNA repair by topologically entrapping DNA. Here, we propose a rigid scaffold model to explain how the cohesin regulators Pds5 and Wapl release cohesin… read more here.
Keywords: rigid scaffold; dna; cohesin; pds5 wapl ... See more keywords
Biochemical and Functional Assays of Human Cohesin-Releasing Factor Wapl.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6545-8_3
Abstract: During the cell cycle, duplicated sister chromatids become physically connected during S phase through a process called sister-chromatid cohesion. Cohesion is terminated during the metaphase-to-anaphase transition to trigger sister-chromatid segregation. The establishment and dissolution of… read more here.
Keywords: cohesin; functional assays; human cohesin; biochemical functional ... See more keywords
The Cohesin Release Factor WAPL Restricts Chromatin Loop Extension
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DOI: 10.1016/j.cell.2017.04.013
Abstract: Summary The spatial organization of chromosomes influences many nuclear processes including gene expression. The cohesin complex shapes the 3D genome by looping together CTCF sites along chromosomes. We show here that chromatin loop size can… read more here.
Keywords: chromatin loop; cohesin; factor wapl; release factor ... See more keywords
The Kinetochore Receptor for the Cohesin Loading Complex
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DOI: 10.1016/j.cell.2017.08.017
Abstract: Summary The ring-shaped cohesin complex brings together distant DNA domains to maintain, express, and segregate the genome. Establishing specific chromosomal linkages depends on cohesin recruitment to defined loci. One such locus is the budding yeast… read more here.
Keywords: receptor cohesin; cohesin; cohesin loading; kinetochore receptor ... See more keywords
Cohesin Can Remain Associated with Chromosomes during DNA Replication
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DOI: 10.1016/j.celrep.2017.08.092
Abstract: Summary To ensure disjunction to opposite poles during anaphase, sister chromatids must be held together following DNA replication. This is mediated by cohesin, which is thought to entrap sister DNAs inside a tripartite ring composed… read more here.
Keywords: cohesin; associated chromosomes; dna replication; remain associated ... See more keywords
Specific Contributions of Cohesin-SA1 and Cohesin-SA2 to TADs and Polycomb Domains in Embryonic Stem Cells
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DOI: 10.1016/j.celrep.2019.05.078
Abstract: Summary Cohesin exists in two variants carrying either STAG/SA1 or SA2. Here we have addressed their specific contributions to the unique spatial organization of the mouse embryonic stem cell genome, which ensures super-enhancer-dependent transcription of… read more here.
Keywords: polycomb domains; cohesin; cohesin sa2; embryonic stem ... See more keywords
Cohesin and chromosome segregation
Sign Up to like & getrecommendations! Published in 2018 at "Current Biology"
DOI: 10.1016/j.cub.2018.05.019
Abstract: Summary Cohesin is a ring-shaped protein complex that organises the genome, enabling its condensation, expression, repair and transmission. Cohesin is best known for its role in chromosome segregation, where it provides the cohesion that is… read more here.
Keywords: cohesin; sister chromatids; chromosome segregation; segregation ... See more keywords
Genome Organization: Cohesin on the Move.
Sign Up to like & getrecommendations! Published in 2017 at "Molecular cell"
DOI: 10.1016/j.molcel.2017.05.002
Abstract: Folding of mammalian genomes into spatial domains is thought to depend on cohesin and CTCF proteins. Busslinger et al. (2017) reveal that transcription moves cohesin along DNA to CTCF-binding sites, providing insights into how cohesin and CTCF… read more here.
Keywords: organization cohesin; cohesin; cohesin move; ctcf ... See more keywords
Principles of Chromosome Architecture Revealed by Hi-C.
Sign Up to like & getrecommendations! Published in 2018 at "Trends in biochemical sciences"
DOI: 10.1016/j.tibs.2018.03.006
Abstract: Chromosomes are folded and compacted in interphase nuclei, but the molecular basis of this folding is poorly understood. Chromosome conformation capture methods, such as Hi-C, combine chemical crosslinking of chromatin with fragmentation, DNA ligation, and… read more here.
Keywords: dna; cohesin; ctcf cohesin; principles chromosome ... See more keywords
Cohesin is positioned in mammalian genomes by transcription, CTCF and Wapl.
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature22063
Abstract: Mammalian genomes are spatially organized by CCCTC-binding factor (CTCF) and cohesin into chromatin loops and topologically associated domains, which have important roles in gene regulation and recombination. By binding to specific sequences, CTCF defines contact… read more here.
Keywords: mammalian genomes; cohesin; transcription ctcf; ctcf ... See more keywords
Transcription-dependent cohesin repositioning rewires chromatin loops in cellular senescence
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DOI: 10.1038/s41467-020-19878-4
Abstract: Senescence is a state of stable proliferative arrest, generally accompanied by the senescence-associated secretory phenotype, which modulates tissue homeostasis. Enhancer-promoter interactions, facilitated by chromatin loops, play a key role in gene regulation but their relevance… read more here.
Keywords: chromatin loops; novo cohesin; cohesin; senescence ... See more keywords