A Genetic Analysis of Tumor Progression in Drosophila Identifies the Cohesin Complex as a Suppressor of Individual and Collective Cell Invasion
Sign Up to like & getrecommendations! Published in 2020 at "iScience"
DOI: 10.1016/j.isci.2020.101237
Abstract: Summary Metastasis is the leading cause of death for patients with cancer. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumor growth toward malignancy. Advances in… read more here.
Keywords: tumor progression; cohesin complex; invasion; progression ... See more keywords
The cohesin complex of yeasts: sister chromatid cohesion and beyond.
Sign Up to like & getrecommendations! Published in 2022 at "FEMS microbiology reviews"
DOI: 10.1093/femsre/fuac045
Abstract: Each time a cell divides, it needs to duplicate the genome and then separate the two copies. In eukaryotes, which usually have more than one linear chromosome, this entails tethering the two newly replicated DNA… read more here.
Keywords: cohesin; chromatid cohesion; chromosome; sister chromatid ... See more keywords
Abstract 1578: Cohesin complex-related genes in colorectal cancer
Sign Up to like & getrecommendations! Published in 2019 at "Epidemiology"
DOI: 10.1158/1538-7445.am2019-1578
Abstract: Backgrounds: One of the hallmarks of cancer is chromosomal instability and it leads to aneuploidy. Defective sister chromatid cohesion represents a major cause of chromosome instability in human cancers. Stromal antigen (STAG) encodes a subunit… read more here.
Keywords: expression; stag3; cohesin complex; cancer ... See more keywords
The Zebrafish Meiotic Cohesin Complex Protein Smc1b Is Required for Key Events in Meiotic Prophase I
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.714245
Abstract: The eukaryotic structural maintenance of chromosomes (SMC) proteins are involved in key processes of chromosome structure and dynamics. SMC1β was identified as a component of the meiotic cohesin complex in vertebrates, which aids in keeping… read more here.
Keywords: meiotic cohesin; cohesin complex; meiosis; smc1b ... See more keywords
Cohesin-Mediated Chromatin Interactions and Autoimmunity
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.840002
Abstract: Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with CCCTC-binding factor, it ensures… read more here.
Keywords: cohesin; cohesin proteins; autoimmunity; cohesin mediated ... See more keywords
BETting on a Transcriptional Deficit as the Main Cause for Cornelia de Lange Syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2021.709232
Abstract: Cornelia de Lange Syndrome (CdLS) is a human developmental syndrome with complex multisystem phenotypic features. It has been traditionally considered a cohesinopathy together with other phenotypically related diseases because of their association with mutations in… read more here.
Keywords: lange syndrome; cohesin complex; function; cdls ... See more keywords
DNA Repair in Space and Time: Safeguarding the Genome with the Cohesin Complex
Sign Up to like & getrecommendations! Published in 2022 at "Genes"
DOI: 10.3390/genes13020198
Abstract: DNA double-strand breaks (DSBs) are a deleterious form of DNA damage, which must be robustly addressed to ensure genome stability. Defective repair can result in chromosome loss, point mutations, loss of heterozygosity or chromosomal rearrangements,… read more here.
Keywords: dna repair; dna; cohesin complex; repair space ... See more keywords