Landscape of cohesin-mediated chromatin loops in the human genome
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DOI: 10.1038/s41586-020-2151-x
Abstract: Physical interactions between distal regulatory elements have a key role in regulating gene expression, but the extent to which these interactions vary between cell types and contribute to cell-type-specific gene expression remains unclear. Here, to… read more here.
Keywords: chromatin loops; cohesin mediated; gene expression; cell ... See more keywords
Abstract A054: Accurate prediction of cohesin-mediated 3D genome organization using 2D chromatin features
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DOI: 10.1158/1538-7445.prca2023-a054
Abstract: The three-dimensional (3D) genome organization influences diverse nuclear processes. Chromatin interaction analysis by paired-end tag sequencing (ChIA-PET) and High-throughput chromatin conformation capture (Hi-C) are powerful methods used to study the 3D genome organization. However, these… read more here.
Keywords: chromatin; chip seq; cohesin mediated; organization ... See more keywords
Regulation of cohesinâmediated chromosome folding by PDS5 in mammals
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DOI: 10.15252/embr.202254853
Abstract: Cohesin regulates sister chromatid cohesion but also contributes to chromosome folding by promoting the formation of chromatin loops, a process mediated by loop extrusion. Although PDS5 regulates cohesin dynamics on chromatin, the exact function of… read more here.
Keywords: cohesin; pds5a pds5b; chromosome folding; cohesin mediated ... See more keywords
Cohesin-Mediated Chromatin Interactions and Autoimmunity
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DOI: 10.3389/fimmu.2022.840002
Abstract: Proper physiological functioning of any cell type requires ordered chromatin organization. In this context, cohesin complex performs important functions preventing premature separation of sister chromatids after DNA replication. In partnership with CCCTC-binding factor, it ensures… read more here.
Keywords: cohesin; cohesin proteins; autoimmunity; cohesin mediated ... See more keywords