Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1
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DOI: 10.1038/s41598-019-47592-9
Abstract: Tropomyosins (Tpm) determine the functional capacity of actin filaments in an isoform-specific manner. The primary isoform in cancer cells is Tpm3.1 and compounds that target Tpm3.1 show promising results as anti-cancer agents both in vivo… read more here.
Keywords: coil overlap; compound atm; tpm3; cancer ... See more keywords