Structural characteristics of coiled‐coil regions in AF10‐DOT1L and AF10‐inhibitory peptide complex
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.1ma0421-010r
Abstract: The interaction of the solo H3K79 methyltransferase DOT1‐like (DOT1L) and its regulatory factor ALL1‐fused gene from chromosome 10 protein (AF10) is crucial for the transcription of developmental genes such as HOXA in acute leukemia. The… read more here.
Keywords: dot1l af10; inhibitory peptide; coil regions; af10 inhibitory ... See more keywords
Efficient Release of Affinity-Captured Cells Using a Coiled-Coil-Based Molecular Trigger.
Sign Up to like & getrecommendations! Published in 2017 at "Macromolecular bioscience"
DOI: 10.1002/mabi.201600330
Abstract: Affinity-based cell separation is label-free and highly specific, but it is difficult to efficiently and gently release affinity-captured cells due to the multivalent nature of cell-material interactions. To address this challenge, we have developed a… read more here.
Keywords: molecular trigger; affinity; captured cells; coiled coil ... See more keywords
A comparison of the collagen triple helix and coiled‐coil peptide building blocks on metal ion‐mediated supramolecular assembly
Sign Up to like & getrecommendations! Published in 2020 at "Peptide Science"
DOI: 10.1002/pep2.24190
Abstract: Metal ion‐mediated assembly of peptides is an intriguing method for developing novel biomaterials. In particular, peptide building blocks based on collagen triple helical and coiled‐coil peptides have been functionalized with metal‐binding ligands and assemble into… read more here.
Keywords: building blocks; collagen triple; coiled coil; metal ion ... See more keywords
Structural destabilization of tropomyosin induced by the cardiomyopathy‐linked mutation R21H
Sign Up to like & getrecommendations! Published in 2018 at "Protein Science"
DOI: 10.1002/pro.3341
Abstract: The missense mutation R21H in striated muscle tropomyosin is associated with hypertrophic cardiomyopathy, a genetic cardiac disease and a leading cause of sudden cardiac death in young people. Tropomyosin adopts conformation of a coiled coil… read more here.
Keywords: tm1a1 28zip; structural destabilization; tropomyosin; mutation r21h ... See more keywords
Reversible crosslinked assembly of a trimeric coiled‐coil peptide into a three‐dimensional matrix for cell encapsulation and release
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Peptide Science"
DOI: 10.1002/psc.3302
Abstract: Mimicking the extracellular matrix (ECM) continues to be a goal in the field of regenerative medicine. Herein, we report a modified trimeric GCN4 coiled‐coil sequence containing three ligands for metal ions specifically positioned for crosslinked… read more here.
Keywords: crosslinked assembly; three dimensional; matrix; cell ... See more keywords
Enhanced Liposomal Drug Delivery Via Membrane Fusion Triggered by Dimeric Coiled-Coil Peptides.
Sign Up to like & getrecommendations! Published in 2023 at "Small"
DOI: 10.1002/smll.202301133
Abstract: An ideal nanomedicine system improves the therapeutic efficacy of drugs. However, most nanomedicines enter cells via endosomal/lysosomal pathways and only a small fraction of the cargo enters the cytosol inducing therapeutic effects. To circumvent this… read more here.
Keywords: membrane fusion; fusion; delivery; coiled coil ... See more keywords
New tetrameric forms of the rotavirus NSP4 with antiparallel helices
Sign Up to like & getrecommendations! Published in 2018 at "Archives of Virology"
DOI: 10.1007/s00705-018-3753-6
Abstract: Rotavirus nonstructural protein 4, the first viral enterotoxin to be identified, is a multidomain, multifunctional glycoprotein. Earlier, we reported a Ca2+-bound coiled-coil tetrameric structure of the diarrhea-inducing region of NSP4 from the rotavirus strains SA11… read more here.
Keywords: rotavirus nsp4; new tetrameric; forms rotavirus; coiled coil ... See more keywords
Phase separation of the LINE-1 ORF1 protein is mediated by the N-terminus and coiled-coil domain.
Sign Up to like & getrecommendations! Published in 2021 at "Biophysical journal"
DOI: 10.1016/j.bpj.2021.03.028
Abstract: Long Interspersed Nuclear Element-1 (LINE-1 or L1) is a retrotransposable element that autonomously replicates in the human genome, resulting in DNA damage and genomic instability. Activation of L1 in senescent cells triggers a type I… read more here.
Keywords: coiled coil; phase separation; coil domain; separation ... See more keywords
Binding mechanism of a de novo coiled coil complex elucidated from surface forces measurements.
Sign Up to like & getrecommendations! Published in 2020 at "Journal of colloid and interface science"
DOI: 10.1016/j.jcis.2020.07.097
Abstract: We used the Surface Forces Apparatus to elucidate the interaction mechanism between grafted 5 heptad-long peptides engineered to spontaneously form a heterodimeric coiled-coil complex. The results demonstrated that when intimate contact between peptides is reached,… read more here.
Keywords: coiled coil; mechanism; surface forces; coil complex ... See more keywords
Orientational Ambiguity in Septin Coiled Coils and its Structural Basis.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2021.166889
Abstract: Septins are an example of subtle molecular recognition whereby different paralogues must correctly assemble into functional filaments important for essential cellular events such as cytokinesis. Most possess C-terminal domains capable of forming coiled coils which… read more here.
Keywords: coiled coils; orientational ambiguity; septin coiled; coiled coil ... See more keywords
Coiled-coil oligomerization controls localization of the plasma membrane REMORINs.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of structural biology"
DOI: 10.1016/j.jsb.2018.02.003
Abstract: REMORINs are nanodomain-organized proteins located in the plasma membrane and involved in cellular responses in plants. The dynamic assembly of the membrane nanodomains represents an essential tool of the versatile membrane barriers to control and… read more here.
Keywords: oligomerization controls; coil oligomerization; coiled coil; membrane ... See more keywords