Coilin as a regulator of NF-kB mediated inflammation in preeclampsia
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DOI: 10.1242/bio.059326
Abstract: ABSTRACT The nuclear factor-Kappa B (NF-κB) pathway is a crucial mediator of inflammatory signaling. Aberrant activation of NF-κB is associated with several disorders including preeclampsia (PE). Many regulators of the NF-κB pathway have been identified,… read more here.
Keywords: mir 517; regulator mediated; coilin regulator; regulator ... See more keywords
A point mutation in human coilin prevents Cajal body formation.
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DOI: 10.1242/jcs.259587
Abstract: Coilin is a conserved protein essential for integrity of nuclear membrane-less inclusions called Cajal bodies. Here, we report an amino-acid substitution (p.K496E) found in a widely-used human EGFP-coilin construct that has a dominant negative effect… read more here.
Keywords: cajal body; body formation; human coilin; cajal bodies ... See more keywords
The Impact of Coilin Nonsynonymous SNP Variants E121K and V145I on Cell Growth and Cajal Body Formation: The First Characterization
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DOI: 10.3390/genes11080895
Abstract: Coilin is the main component of Cajal body (CB), a membraneless organelle that is involved in the biogenesis of ribonucleoproteins and telomerase, cell cycle, and cell growth. The disruption of CBs is linked to neurodegenerative… read more here.
Keywords: coilin; formation; cell growth; v145i ... See more keywords