Coamplification of 12q15 and 12p13 and homozygous CDKN2A/2B deletion: synergistic role of fibrosarcomatous transformation in dermatofibrosarcoma protuberans with a cryptic COL1A1-PDGFB fusion
Sign Up to like & getrecommendations! Published in 2022 at "Virchows Archiv"
DOI: 10.1007/s00428-022-03297-5
Abstract: Dermatofibrosarcoma protuberans (DFSP) is characterized by collagen type I alpha 1 chain-platelet-derived growth factor B chain (COL1A1-PDGFB) fusion. We present a case of fibrosarcomatous DFSP with lung metastasis in a 53-year-old man. Histologically, the primary… read more here.
Keywords: coamplification; col1a1 pdgfb; fusion; pdgfb fusion ... See more keywords
COL1A1–PDGFB Fusion Gene Detection Through Bulk RNA-Seq and Transcriptomic Features of Dermatofibrosarcoma Protuberans
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DOI: 10.1097/dss.0000000000003771
Abstract: Supplemental Digital Content is Available in the Text. BACKGROUND Dermatofibrosarcoma protuberans (DFSP) is a cutaneous sarcoma with obscure origin and multidirectional differentiation. Application of RNA-Seq in the detection of COL1A1–PDGFB is still at early stages.… read more here.
Keywords: rna seq; rna; col1a1 pdgfb; detection ... See more keywords
COL1A1-PDGFB Fusion Associated Fibrosarcoma of the Uterine Corpus: A Case Report and Literature Review
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DOI: 10.1097/pgp.0000000000000850
Abstract: Uterine collagen type 1 alpha 1 (COL1A1) and platelet-derived growth factor beta chain (PDGFB) fusion associated fibrosarcoma is a recently described entity characterized by a specific translocation t(17;22) (q22;q13) leading to the formation of COL1A1-PDGFB… read more here.
Keywords: associated fibrosarcoma; fusion; col1a1 pdgfb; pdgfb fusion ... See more keywords
Pediatric dermatofibrosarcoma protuberans: A clinicopathologic and genetic analysis of 66 cases in the largest institution in Southwest China
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1017154
Abstract: Background Dermatofibrosarcoma protuberans (DFSP) is an uncommon cutaneous tumor in children. Most published articles are sporadic or small series and lack systematically molecular analyses. The aim of our study is to better understand the clinicopathologic… read more here.
Keywords: clinicopathologic genetic; col1a1 pdgfb; pdgfb fusion; pediatric dermatofibrosarcoma ... See more keywords